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The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice

ABSTRACT: The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice

PROVIDER: PRJNA943487 | ENA |

REPOSITORIES: ENA

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	SRR23821369.fastq.gz	Fastqsanger.gz
	SRR23821370.fastq.gz	Fastqsanger.gz
	SRR23821371.fastq.gz	Fastqsanger.gz
	SRR23821372.fastq.gz	Fastqsanger.gz

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The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice

Project description:While depression and chronic pain are frequently comorbid, underlying neuronal circuits, and their relevance for the understanding of psychopathology, remain poorly defined. Here we show in mice that hyperactivity of the neuronal pathway linking the basolateral amygdala to the anterior cingulate cortex is essential for chronic pain-induced depression. In naive male mice, we demonstrate that activation of this pathway is sufficient to trigger depressive-like behaviors, as well as transcriptomic alterations that recapitulate core molecular features of depression in the human brain. These alterations notably impact gene modules related to myelination and the oligodendrocyte lineage. Among these, we show that Sema4a, a hub gene significantly upregulated in both male mice and humans in the context of altered mood, is necessary for the emergence of depressive-like behaviors. Overall, these results place the BLA-ACC pathway at the core of pain and depression comorbidity, and unravel the role of impaired myelination and Sema4a in mood control.

2023-04-26 | GSE227159 | GEO

Anterior cingulate cortex mediates the comorbidity between colorectal cancer and depression-like behaviors

Project description:In this study, we established mice with orthotopic colorectal cancer (CRC mice) and observed depression-like behaviors in the CRC mice. Through whole-brain c-FOS mapping, functional connectivity analysis, gut-brain inverse mapping, and correlation analysis, combined with chemogenetic manipulation, we identified the anterior cingulate cortex (ACC) as a key hub in the depression-related brain network. we performed whole transcriptome sequencing of key neural nuclei to identify molecular changes associated with CRC-depression comorbidity. Furthermore, chemogenetic modulation of neuronal excitability not only alleviated depression-like behavior but also reduced CRC progression in these mice. Importantly, our findings suggest that targeting the ACC, in addition to conventional colorectal cancer therapies, could offer therapeutic and quality-of-life benefits for patients with both CRC and depression.

2024-11-20 | GSE281840 | GEO

Anterior cingulate cortex mediates the comorbidity between colorectal cancer and depression-like behaviors

Project description:Anterior cingulate cortex mediates the comorbidity between colorectal cancer and depression-like behaviors

| PRJNA1185799 | ENA

Astrocyte molecular changes during basolateral amygdala-related emotional behaviors

Project description:Astrocyte molecular changes during basolateral amygdala-related emotional behaviors

| PRJNA1201265 | ENA

The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice.

Project description: Not available

| S-EPMC10110607 | biostudies-literature

Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set6]

Project description:Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set6]

| PRJNA1445976 | ENA

Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set5]

Project description:Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set5]

| PRJNA1445979 | ENA

Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set7]

Project description:Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set7]

| PRJNA1445986 | ENA

Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set8]

Project description:Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set8]

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Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set1]

Project description:Astrocyte molecular changes during basolateral amygdala-related emotional behaviors [set1]

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