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Drosophila melanogaster strain:w1118

ABSTRACT: Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte nuclear factor 4

PROVIDER: PRJNA945078 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23878910_1.fastq.gz	Fastqsanger.gz
	SRR23878910_2.fastq.gz	Fastqsanger.gz
	SRR23878911_1.fastq.gz	Fastqsanger.gz
	SRR23878911_2.fastq.gz	Fastqsanger.gz
	SRR23878912_1.fastq.gz	Fastqsanger.gz

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Project description:Social experience and pheromone signaling in ORNs affect pheromone responses and male courtship behaviors in Drosophila, however, the molecular mechanisms underlying this circuit-level neuromodulation remain less clear. Previous studies identified social experience and pheromone signaling-dependent modulation of chromatin around behavioral switch gene fruitless, which encodes a transcription factor necessary and sufficient for male behaviors. To identify the molecular mechanisms driving social experience-dependent neuromodulation, we performed RNA-seq from antennal samples of mutant fruit flies in pheromone receptors and fruitless, as well as grouped or isolated wild-type males. We found that loss of pheromone detection differentially alters the levels of fruitless exons suggesting changes in splicing patterns. In addition, many Fruitless target neuromodulatory genes, such as neurotransmitter receptors, ion channels, and ion transporters, are differentially regulated by social context and pheromone signaling. Our results suggest that modulation of circuit activity and behaviors in response to social experience and pheromone signaling arise due to changes in transcriptional programs for neuromodulators downstream of behavioral switch gene function.

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