Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Double strand break repair protein TIRR regulates RNA metabolism in response to DNA damage and cell stress

ABSTRACT: Double strand break repair protein TIRR regulates RNA metabolism in response to DNA damage and cell stress

PROVIDER: PRJNA946638 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23913649_1.fastq.gz	Fastqsanger.gz
	SRR23913649_2.fastq.gz	Fastqsanger.gz
	SRR23913650_1.fastq.gz	Fastqsanger.gz
	SRR23913650_2.fastq.gz	Fastqsanger.gz
	SRR23913651_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Double strand break repair protein TIRR regulates RNA metabolism in response to DNA damage and cell stress [RNA-Seq]

Project description:Tudor interacting repair regulator (TIRR) is a well-studied p53 binding protein 1 (53BP1) interactor in response to DNA double strand breaks (DSBs). TIRR is also an RNA binding protein, however its role in RNA regulation in response to cellular insults is not understood. Here we show that TIRR binds to specific group of mRNAs in response to DNA damage. TIRR bound transcripts encode for transcription factors and RNA polymerase II (RNAPII) transcription regulators. Furthermore, TIRR modulates the formation of RNA processing bodies (P bodies/PBs), in response to DSBs. TIRR also regulates the formation of the closely related but distinct compartments known as stress granules (SGs) in response to cell stress. Furthermore, TIRR dissociates from 53BP1 in response to sodium arsenite treatment independently of Ataxia Telangiectasia Mutated Protein (ATM) signalling. Finally, TIRR interacts with the nuclear export protein Exportin-1 (XPO1) upon DNA damage. TIRR bound RNA co-localises with PB and SGs and TIRR depletion leads to nuclear RNA retention. This work reveals that TIRR orchestrates mRNA nuclear export, metabolism and storage in PBs/SGs. Hence TIRR regulates RNA mediated DNA damage and cell stress responses independently of its canonical 53BP1 binding role.

2024-07-18 | GSE248032 | GEO

Double strand break repair protein TIRR regulates RNA metabolism in response to DNA damage and cell stress [RIP-seq]

2024-07-18 | GSE227684 | GEO

RecG Directs DNA Synthesis During Double-Strand Break Repair [ChIP-seq]

Project description:In the bacterium Escherichia coli, RecG directs DNA synthesis during the repair of DNA double-strand breaks by homologous recombination. Examination of RecA binding during double-strand break repair in Escherichia coli in the presence and absence of RecG protein

2016-05-19 | E-GEOD-77181 | biostudies-arrayexpress

CGH of Drosophila Follicle Cell Amplicons in double-strand break repair mutants

Project description:CGH of stage 13 amplifying follicle cells to measure changes in replication fork progression in double-strand break repair mutants Comparative genomic hybridization was performed to compare amplification gradients of stage 13 follicle cells from several double-strand break repair mutants to wild type (OrR) gradients. Two-three replicates were done for each genotype.

2017-02-08 | GSE86012 | GEO

Double strand break repair protein TIRR regulates RNA metabolism in response to DNA damage and cell stress [RIP-seq]

Project description:Double strand break repair protein TIRR regulates RNA metabolism in response to DNA damage and cell stress [RIP-seq]

| PRJNA946642 | ENA

Double strand break repair protein TIRR regulates RNA metabolism in response to DNA damage and cell stress [RNA-Seq]

Project description:Double strand break repair protein TIRR regulates RNA metabolism in response to DNA damage and cell stress [RNA-Seq]

| PRJNA1041432 | ENA

Distribution of Holliday Junctions and Repair Forks during Escherichia coli DNA Double-Strand Break Repair

Project description:Here, we correlated and compared two different steps of the Double-Strand Break Repair pathway: RecA loading and Holliday junction formation

2021-07-29 | GSE179963 | GEO

RecG Directs DNA Synthesis During Double-Strand Break Repair

Project description:RecG Directs DNA Synthesis During Double-Strand Break Repair

| PRJNA309667 | ENA

Genomic Analysis of DNA Double-Strand Break Repair in Escherichia coli

Project description:Counting DNA reads using whole genome sequencing is providing new insight into DNA double-strand break repair (DSBR) in the model organism Escherichia coli. We describe the application of RecA chromatin immunoprecipitation coupled to genomic DNA sequencing (RecA-ChIP-seq) and marker frequency analysis (MFA) to analyse the genomic consequences of DSBR.

2019-01-03 | GSE117541 | GEO

DNA Double Strand Break Repair in E. coli Perturbs Cell Division and Chromosome Dynamics

Project description:The effect of a site-specific DNA double-strand break on the abundance of E. coli chromosomal DNA during exponential growth was investigated by marker frequency analysis (MFA).

2020-01-20 | GSE141011 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data