Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Relapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics

ABSTRACT: Relapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics

PROVIDER: PRJNA948040 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Relapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics [DNA methylation]

Project description:Relapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics [DNA methylation]

| PRJNA948028 | ENA

Relapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics [RNA-seq]

Project description:Relapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics [RNA-seq]

| PRJNA948039 | ENA

Human pluripotent stem cell-derived brain tumor model uncovered embryonic stem cell signature as a key driver in atypical teratoid/rhabdoid tumor (microarray)

2019-06-20 | GSE118653 | GEO

Relapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-15 | GSE228103 | GEO

Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics.

Project description: Not available

| S-EPMC10412492 | biostudies-literature

Relapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics [RNA-seq]

Project description:Here, we investigated tumor tissue from 26 patients affected by AT/RT to identify signatures of recurrences in comparison to matched primary tumor samples. Therefore, we performed histological analysis and DNA methylation and gene expression profiling.

2023-07-15 | GSE228101 | GEO

Relapsed atypical teratoid/rhabdoid tumors (AT/RT) reveal distinct features of progression on histology, epigenetics, copy number profiling, and transcriptomics [DNA methylation]

Project description:Here, we investigated tumor tissue from 26 patients affected by AT/RT to identify signatures of recurrences in comparison to matched primary tumor samples.

2023-07-15 | GSE228091 | GEO

Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors.

Project description:Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive CNS-tumors of infancy and early childhood. Hallmark is the surprisingly simple genomics with a truncating mutation in the SMARCB1 gene as the oncogenic driver. Nevertheless, AT/RTs are infiltrated by immune cells and even clonally expanded T-cells. However, it is unclear, what T-cells might recognize on AT/RT cells. Here, we report a comprehensive analysis of naturally presented HLA-class-I and class-II ligands on n=23 AT/RTs. MS-based analysis of the HLA-ligandome revealed 55 class-I and 139 class-II peptides from tumor-associated proteins.

2022-05-31 | PXD033935 | Pride

RNA sequencing data from primary atypical teratoid rhabdoid tumor (ATRT) samples

Project description:Atypical teratoid/rhabdoid tumors (ATRTs) are very aggressive childhood malignancies of the central nervous system. The underlying genetic cause are inactivating bi-allelic mutations in SMARCB1 or (rarely) in SMARCA4. The purpose of this study was to compare the transcriptomes of ATRTs with SMARCA4 mutations to those carrying SMARCB1 mutations.

2020-12-18 | GSE160748 | GEO

Human pluripotent stem cell-derived brain tumor model uncovered embryonic stem cell signature as a key driver in atypical teratoid/rhabdoid tumor (RNA-Seq)

Project description:Atypical teratoid/rhabdoid tumor (AT/RT), which harbors INI1 mutation and exhibits a characteristic histology of rhabdoid cells, has a poor prognosis because of the lack of effective treatments. Here we established human INI1-deficient pluripotent stem cells (hPSCs), which developed AT/RT formation in vivo. We revealed that the activation of ESC-like signature leads to rhabdoid phenotype in tumor by OSKM or c-MYC induction. Finally, we performed CRISPR/Cas9 knockout screening to inhibit activation of ESC-like signature in AT/RT. Our effort identified candidate genes including RAD21 that encodes a key component within the cohesin complex. Notably, chemical inhibition of HDAC8 that indirectly targets the function of cohesin with simultaneous inhibition of EZH2 efficiently suppressed the activation of ESC-like signature and inhibited the growth of AT/RT cells both in vitro and in vivo.

2019-06-20 | GSE118654 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data