Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Nanoplastics-16s

ABSTRACT: Nanoplastics-16s Raw sequence reads

PROVIDER: PRJNA948176 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24087100.fastq.gz	Fastqsanger.gz
	SRR24087101.fastq.gz	Fastqsanger.gz
	SRR24087102.fastq.gz	Fastqsanger.gz
	SRR24087103.fastq.gz	Fastqsanger.gz
	SRR24087104.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 156

Similar Datasets

16S

Project description:16S Raw sequence reads

| PRJNA1195610 | ENA

16S

Project description:16S Raw sequence reads

| PRJNA786611 | ENA

Morus alba Raw protein sequence reads

Project description:Morus alba L. Raw protein sequence reads and sequence

2024-02-08 | PXD049451 |

Gut-Lung Microbiota Dynamics in Mice Exposed to Nanoplastics

Project description:The objective was to evaluate the impact of nanoplastics on various niches of the microbiome in a mouse model

2024-10-21 | GSE265766 | GEO

16S sequence

Project description:16S sequence Raw sequence reads

| PRJNA883002 | ENA

Oral ingestion of polystyrene nanoplastics causes memory impairment and neuroinflammation by microglial uptake

Project description:Nanoplastics are produced by breakdown of plastics in environmental contamination or commercial use for cosmetics or daily expenses. Emerging evidence indicate that ingested nanoplastics with a size smaller than 100 nm have the potential to reach the brain and induces neurotoxicity. However, the potential toxicity of nanoplastics on brain are limited because of difficulties in synthesize of nanoplastics. In present study, we synthesized the fluorescent polystyrene nanoplastics (PSNPs) and examined the toxicity of PSNPs in brain in vivo and in vitro analyses by comparison to IR-813 fluorophore. Synthesized PSNPs were characterized by fluorescence imaging system, scanning electron microscopy, and Fourier-transform infrared spectroscopy. PSNPs were detected in adult mice brain by oral ingestion. In addition, a series of behavioral analyses showed that oral ingestion of PSNPs induced memory impairments. Among brain cells, PSNPs were predominantly internalized in microglia, and uptake of PSNPs induced microglial activation. In addition, the conditioned medium derived from microglia exposed to PSNPs repressed hippocampal neuronal activity. Furthermore, transcriptome analysis showed that PSNPs changed gene expressions in microglia, elevation of neuroinflammation in contrast to suppression of neurotrophic factors. These results indicated that predominant uptake of PSNPs in microglia induced elevation of neuroninflammatory responses whereas suppression of neurotrophic factors that may contribute to the cognitive impairment. Our findings indicate the toxic mechanism and potential detrimental effect of nanoplastic in brain and suggest a potential risk of cognitive impairment by exposure to nanoplastics.

2023-09-24 | GSE243612 | GEO

Single-cell transcriptome profile of mouse gallbladder cells after nanoplastics exposure

Project description:To understand molecular events of gallbladder cells during nanoplastics exposure, we performed scRNA-seq on gallbladder using 10x Genomics Chromium platform

2025-01-01 | GSE254778 | GEO

16S

Project description:Magic Microbiome 16S Raw sequence reads

| PRJNA796289 | ENA

sediment 16s

Project description:sediment 16s Raw sequence reads

| PRJNA1102934 | ENA

16S community

Project description:16S community Raw sequence reads

| PRJNA529059 | ENA