Project description:Bulk RNA-seq was performed on a monoclonal nilotinib-resistant cell line derived from parental JURL-MK1 cells and on parental JURL-MK1 cells. The aim of the study was to identify the molecular differences between the two cell lines.
Project description:Bulk RNA-seq analysis was performed across a 72 hr timecourse for JURL-MK1 cells in which the dopamine receptors DRD3 or DRD4 were knocked down by lentiviral mediated shRNAs in vitro. Knockdown cells were also treated with and without a TKI (nilotinib.