Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

LXR signaling controls homeostatic dendritic cell maturation [scRNAseq]

ABSTRACT: LXR signaling controls homeostatic dendritic cell maturation [scRNAseq]

PROVIDER: PRJNA950319 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24015742.fastq.gz	Fastqsanger.gz
	SRR24015743.fastq.gz	Fastqsanger.gz
	SRR24015744.fastq.gz	Fastqsanger.gz
	SRR24015745.fastq.gz	Fastqsanger.gz
	SRR24015746.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

LXR signaling controls homeostatic dendritic cell maturation

Project description:LXR signaling controls homeostatic dendritic cell maturation

| PRJNA950314 | ENA

LXR signaling controls homeostatic dendritic cell maturation [scRNAseq]

Project description:Depending on how an antigen is perceived, dendritic cells (DCs) mature in an immunogenic or tolerogenic manner, safeguarding the balance between immunity and tolerance. Whereas the pathways driving immunogenic maturation in response to infectious insults are well characterized, the signals driving tolerogenic maturation in homeostasis are still poorly understood. Here we demonstrate that engulfment of apoptotic cells triggers homeostatic maturation of conventional cDC1s in the spleen. This process can be modeled by engulfment of empty, non-adjuvanted lipid nanoparticles (LNPs), is marked by intracellular accumulation of cholesterol, and highly unique to type 1 DCs. Engulfment of apoptotic cells or cholesterol-rich LNPs leads to activation of the LXR pathway driving cellular cholesterol efflux and repression of immunogenic genes. In contrast, simultaneous engagement of TLR3 to mimic viral infection via administration of poly(I:C)-adjuvanted LNPs represses the LXR pathway, thus delaying cellular cholesterol efflux and inducing genes that promote T cell immunity. These data demonstrate how DCs exploit the conserved cellular cholesterol efflux pathway to regulate induction of tolerance or immunity and reveal that administration of non-adjuvanted cholesterol-rich LNPs is a powerful platform for inducing tolerogenic DC maturation.

2023-03-30 | GSE228544 | GEO

LXR signaling controls homeostatic dendritic cell maturation [BulkRNAseq]

Project description:LXR signaling controls homeostatic dendritic cell maturation [BulkRNAseq]

| PRJNA950098 | ENA

LXR signaling controls homeostatic dendritic cell maturation [BulkRNAseq]

2023-03-30 | GSE228523 | GEO

The unfolded protein sensor IRE1 is essential for homeostatic dendritic cell maturation

Project description:The unfolded protein sensor IRE1 is essential for homeostatic dendritic cell maturation

| PRJNA1127625 | ENA

LXR and RAR activation modulate TREM-1 expression in dendritic cells

Project description:Dendritic cells (DCs) play a crucial role in the regulation of innate and adaptive immune responses. DCs initiate adaptive immune responses after their migration to secondary lymphoid organs, a process mainly driven by the expression of the chemokine receptor CCR7. LXR ligands/oxysterols released by tumors were shown to dampen DC migration to secondary lymphoid organs by the inhibition of CCR7 expression. We studied the gene expression modulation of DCs undergoing maturation (by LPS) in the presence of the oxysterol 22R-Hydroxycholesterol (22R-HC).

2019-02-27 | E-MTAB-6224 | biostudies-arrayexpress

The unfolded protein sensor IRE1 is essential for homeostatic dendritic cell maturation [RNA-seq]

Project description:The unfolded protein sensor IRE1 is essential for homeostatic dendritic cell maturation [RNA-seq]

| PRJNA1127635 | ENA

The unfolded protein sensor IRE1 is essential for homeostatic dendritic cell maturation [CITE-seq]

Project description:The unfolded protein sensor IRE1 is essential for homeostatic dendritic cell maturation [CITE-seq]

| PRJNA1127636 | ENA

LXR signaling controls homeostatic dendritic cell maturation

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-03-30 | GSE228545 | GEO

The unfolded protein sensor IRE1 is essential for homeostatic dendritic cell maturation [small RNA-seq]

Project description:The unfolded protein sensor IRE1 is essential for homeostatic dendritic cell maturation [small RNA-seq]