Project description:Investigation of whole genome gene expression level changes in a Lysobacter enzymogenes OH11 delta-clp mutant, compared to the wild-type strain.
Project description:Primary objectives: Study the chemopreventive potential of 5-aminosalicylic acid (5-ASA) and ursodeoxycholic acid (UDCA) in UC by evaluating the effect of treatment on abberant crypt foci (ACF) number, size and rate of dysplasia.
Primary endpoints: 1) Study the chemopreventive potential of 5-ASA and UDCA in UC by evaluating the effect of treatment on ACF number.2) Gain mechanistic insight into the chemopreventive properties of 5-ASA and UDCA by genome-wide array based mRNA expression analysis of UC normal colonic mucosa before and after treatment.
