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Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.

ABSTRACT: Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.

PROVIDER: PRJNA952502 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24071376_1.fastq.gz	Fastqsanger.gz
	SRR24071376_2.fastq.gz	Fastqsanger.gz
	SRR24071377_1.fastq.gz	Fastqsanger.gz
	SRR24071377_2.fastq.gz	Fastqsanger.gz
	SRR24071378_1.fastq.gz	Fastqsanger.gz

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Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages [ATAC-seq]

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Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.

Project description:The touch dome (TD) keratinocytes are specialized epidermal cells that intimately associate with the light touch sensing Merkel cells (MCs). The TD keratinocytes function as a niche for the MCs and can induce de novo hair follicles upon stimulation; however, how the TD keratinocytes are maintained during homeostasis remains unclear. scRNA-seq identified a specific TD keratinocyte marker, Tenascin-C (TNC). Lineage tracing of Tnc-expressing TD keratinocytes revealed that these cells maintain themselves as an autonomous epidermal compartment and give rise to MCs upon injury. Molecular characterization uncovered that, while the transcriptional and chromatin landscape of the TD keratinocytes is remarkably similar to that of the interfollicular epidermal keratinocytes, it also shares certain molecular signatures with the hair follicle keratinocytes. Our study highlights that the TD keratinocytes in the adult skin have molecular characteristics of keratinocytes of diverse epidermal lineages.

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Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.

Project description:This SuperSeries is composed of the SubSeries listed below.

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Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages [RNA-seq]

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Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages [ATAC-seq]

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Identification of the epithelial progenitor niche for the Merkel cell lineage

Project description:Transcriptional profile of murine touch dome keratinocytes sorted on the basis of alpha6-integrin, CD34, Sca1 and CD200 surface markers. Compared to the transcriptional profile of murine interfollicular epidermis (IFE) without the touch dome keratinocytes

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Comparison of tenascin-C proficient versus tenascin-C deficient Mouse Embryonic Fibroblasts (MEFs)

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Comparison of tenascin-C proficient versus tenascin-C deficient Mouse Embryonic Fibroblasts (MEFs)

Project description:In order to investigate what signalling pathways are turned on by tenascin-C, we generated Mouse Embryonic Fibroblasts (MEFs) deficient for tenascin-C and compared their gene expression profile to MEFs proficient for tenascin-C. TNC-KO MEFs as well as WT MEFs in which tenascin-C was knocked-down (following stable transfection of a short hairpin RNA) were compared to WT MEFs (expressing strong endogenous levels of tenascin-C).

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A MYC2, MYC3, MYC4-dependent transcription factor network regulates touch responses in plants

Project description:Plants are continuously exposed to environmental triggers, including mechanical stimulation. Our results demonstrate that jasmonic acid (JA)-signalling not only plays a key role in touch-induced developmental changes, but also in the very early gene expression changes. Using multi-omics, we show that the JA-activated transcription factors MYC2/MYC3/MYC4 co-regulate touch-induced gene expression of 266 genes. MYC2/3/4 particularly activate top touch-induced genes, which peak around 25 minutes and then rapidly decline by 40-60 minutes. ChIP-seq shows that MYC2 dynamically binds hundreds of touch-induced promoters within 25 minutes. Furthermore, promoter activation assays confirm that MYC2 directly activates touch-induced promoters. By combining these data, we identified a core MYC2/3/4-dependent ‘touch regulon’, containing many previously-unknown MYC2 targets like bHLH19 and ERF109. bHLH19 can in turn directly activate the ORA47 promoter, indicating that MYC2/3/4 initiate a hierarchical network of downstream transcription factors. Finally, hormone profiling shows that the rapid touch-induced accumulation of JA/JA-isoleucine is directly controlled by MYC2/3/4 in a positive amplification loop regulating JA-biosynthesis genes.

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