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An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response

ABSTRACT: An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response

PROVIDER: PRJNA953420 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24107700_1.fastq.gz	Fastqsanger.gz
	SRR24107700_2.fastq.gz	Fastqsanger.gz
	SRR24107701_1.fastq.gz	Fastqsanger.gz
	SRR24107701_2.fastq.gz	Fastqsanger.gz
	SRR24107702_1.fastq.gz	Fastqsanger.gz

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An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response

Project description:We have identified and characterized an allelic series of spontaneous Rorb mutations in mice We perform RNASeq to identify gene expression changes associated with Rorb mutations in brain and spinal cord from all five mutant strains. We also perform CNS region-specific RNASeq in the Rorbh5/h5 mutant.

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An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response.

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