Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [5XFAD Toxseq]

ABSTRACT: Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [5XFAD Toxseq]

PROVIDER: PRJNA954304 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24127900.fastq.gz	Fastqsanger.gz
	SRR24127901.fastq.gz	Fastqsanger.gz
	SRR24127902.fastq.gz	Fastqsanger.gz
	SRR24127903.fastq.gz	Fastqsanger.gz
	SRR24127904.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

Project description:Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

| PRJNA954299 | ENA

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [scRNAseq]

Project description:Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [scRNAseq]

| PRJNA954303 | ENA

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [plasma RNAseq]

Project description:Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [plasma RNAseq]

| PRJNA954305 | ENA

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [5XFAD Toxseq]

Project description:Blood protein extravasation through a disrupted blood–brain barrier and innate immune activation are hallmarks of neurological diseases and emerging therapeutic targets. However, how blood proteins polarize innate immune cells remains largely unknown. Here, we established an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline to define the transcriptome and global phosphoproteome of blood-induced innate immune polarization and its role in microglia neurotoxicity. Blood induced widespread microglial transcriptional changes, including changes involving oxidative stress and neurodegenerative genes. Comparative functional multiomics showed that blood proteins induce distinct receptor-mediated transcriptional programs in microglia and macrophages, such as redox, type 1 interferon and lymphocyte recruitment. Deletion of the blood coagulation factor fibrinogen largely reversed blood-induced microglia neurodegenerative signatures. Genetic elimination of the fibrinogen-binding motif to CD11b in Alzheimer’s disease mice reduced microglial lipid metabolism and neurodegenerative signatures that were shared with autoimmune-driven neuroinflammation in multiple sclerosis mice. Our data provide an interactive resource for investigation of the immunology of blood proteins that could support therapeutic targeting of microglia activation by immune and vascular signals.

2023-06-02 | GSE229372 | GEO

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [scRNA-Seq II]

Project description:Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [scRNA-Seq II]

| PRJNA955233 | ENA

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

2023-06-02 | PXD021230 | Pride

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [scRNAseq]

2023-06-02 | GSE229373 | GEO

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [plasma RNAseq]

2023-06-02 | GSE229375 | GEO

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling [scRNA-Seq II]

2023-06-02 | GSE229655 | GEO

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling.

Project description:Blood protein extravasation through a disrupted blood-brain barrier and innate immune activation are hallmarks of neurological diseases and emerging therapeutic targets. However, how blood proteins polarize innate immune cells remains largely unknown. Here, we established an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline to define the transcriptome and global phosphoproteome of blood-induced innate immune polarization and its role in microglia neurotoxicity. Blood induced widespread microglial transcriptional changes, including changes involving oxidative stress and neurodegenerative genes. Comparative functional multiomics showed that blood proteins induce distinct receptor-mediated transcriptional programs in microglia and macrophages, such as redox, type I interferon and lymphocyte recruitment. Deletion of the blood coagulation factor fibrinogen largely reversed blood-induced microglia neurodegenerative signatures. Genetic elimination of the fibrinogen-binding motif to CD11b in Alzheimer's disease mice reduced microglial lipid metabolism and neurodegenerative signatures that were shared with autoimmune-driven neuroinflammation in multiple sclerosis mice. Our data provide an interactive resource for investigation of the immunology of blood proteins that could support therapeutic targeting of microglia activation by immune and vascular signals.

| S-EPMC10307624 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data