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PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate

ABSTRACT: PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate

PROVIDER: PRJNA954355 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24135600.fastq.gz	Fastqsanger.gz
	SRR24135601.fastq.gz	Fastqsanger.gz
	SRR24135602.fastq.gz	Fastqsanger.gz
	SRR24135603.fastq.gz	Fastqsanger.gz
	SRR24135604.fastq.gz	Fastqsanger.gz

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PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (RNA-Seq)

Project description:PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (RNA-Seq)

| PRJNA954362 | ENA

PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (ATAC-Seq)

Project description:PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (ATAC-Seq)

| PRJNA954359 | ENA

PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (Mnase-Seq)

Project description:PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (Mnase-Seq)

| PRJNA954361 | ENA

PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (ChIP-Seq)

Project description:PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (ChIP-Seq)

| PRJNA954360 | ENA

PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (RNA-Seq)

Project description:Hematopoietic stem and progenitor cells (HSPCs) need require tight transcriptional regulation. In-depth knowledge on how epigenetic mechanisms regulate chromatin landscape in order to control gene expression, particularly in response to external stimuli, will be key to understand the pathogenesis of hematologic disorders and improve blood stem cell-based therapies. Prostaglandin E2 (PGE2) and its metabolically resistant analog 16,16-dimethyl-PGE2 (dmPGE2) were previously identified as a potent external stimulus to enhance HSPC engraftment. PGE2 has been evaluated in various clinical trials to improve engraftment of stem cells. To understand the mechanism of gene expression changes, Wwe identified that dmPGE2 mediates chromatin flexibility at HSPC-specific enhancers through histone-variant H2A.Z acetylation to promote master transcription factor (TF) binding and reinforce expression of genes involved in stem cell fate and engraftment.

2024-06-10 | GSE229398 | GEO

PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (Mnase-Seq)

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PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (ChIP-Seq)

2024-06-10 | GSE229396 | GEO

PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate (ATAC-Seq)

2024-06-10 | GSE229395 | GEO

PGE2 alters chromatin through H2A.Zvariant enhancer nucleosome modification to promote hematopoietic stem cell fate

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-10 | GSE229399 | GEO

Mouse PPAR gamma with/without 15-keto-PGE2

Project description:15-keto-PGE2 is proposed as an endogenous ligand of PPAR gamma. The modification of 15-keto-PGE2 can induce PPAR gamma transcriptional activation. This project aims to identify the binding site of 15-keto-PGE2 on PPAR gamma.

2025-02-17 | PXD059654 | Pride

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