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Gene expression profile at single cell level of plasma cells (PCs) from human bone marrow

ABSTRACT: Gene expression profile at single cell level of plasma cells (PCs) from human bone marrow

PROVIDER: PRJNA956893 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24205012.fastq.gz	Fastqsanger.gz
	SRR24205013.fastq.gz	Fastqsanger.gz
	SRR24205014.fastq.gz	Fastqsanger.gz
	SRR24205015.fastq.gz	Fastqsanger.gz

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Gene expression profile at single cell level of plasma cells (PCs) from human bone marrow

Project description:Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs, but are reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of different tissue-resident (Tr)PC populations revealed that they each have their own transcriptional signature indicative of functional adaptation to the host tissue environment. In contrast to expectation, all TrPCs were extremely long-lived, regardless of their organ of residence, with the longevity influenced by intrinsic factors like the immunoglobulin isotype. Analysis at single-cell resolution revealed that the bone marrow is unique in housing a compendium of PCs generated all over the body that retain aspects of the transcriptional program indicative of their tissue of origin.

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