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Members of an array of zinc finger proteins specify distinct Hox chromatin boundaries

ABSTRACT: Members of an array of zinc finger proteins specify distinct Hox chromatin boundaries

PROVIDER: PRJNA961190 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24293105.fastq.gz	Fastqsanger.gz
	SRR24293106.fastq.gz	Fastqsanger.gz
	SRR24293107.fastq.gz	Fastqsanger.gz
	SRR24293108.fastq.gz	Fastqsanger.gz
	SRR24293109.fastq.gz	Fastqsanger.gz

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Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries.

Project description:Partitioning of repressive from actively transcribed chromatin in mammalian cells fosters cell-type-specific gene expression patterns. While this partitioning is reconstructed during differentiation, the chromatin occupancy of the key insulator, CCCTC-binding factor (CTCF), is unchanged at the developmentally important Hox clusters. Thus, dynamic changes in chromatin boundaries must entail other activities. Given its requirement for chromatin loop formation, we examined cohesin-based chromatin occupancy without known insulators, CTCF and Myc-associated zinc-finger protein (MAZ), and identified a family of zinc-finger proteins (ZNFs), some of which exhibit tissue-specific expression. Two such ZNFs foster chromatin boundaries at the Hox clusters that are distinct from each other and from MAZ. PATZ1 was critical to the thoracolumbar boundary in differentiating motor neurons and mouse skeleton, while ZNF263 contributed to cervicothoracic boundaries. We propose that these insulating activities act with cohesin, alone or combinatorially, with or without CTCF, to implement precise positional identity and cell fate during development.

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Members of an array of zinc finger proteins specify distinct Hox chromatin boundaries

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-08-21 | GSE230482 | GEO

Members of an array of zinc finger proteins specify distict Hox chromatin boundaries [Micro-C]

Project description:In this experiment, we sought to identify how genome organization change in WT versus PATZ1 KO cells during differentiation of mouse embryonic stem cells (ESCs) into cervical motor neurons (MNs).

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Members of an array of zinc finger proteins specify distict Hox chromatin boundaries [ChIP-seq]

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