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Apelin 13 breaks the immune cell route from lung to brain [scRNA-Seq]

ABSTRACT: Apelin 13 breaks the immune cell route from lung to brain [scRNA-Seq]

PROVIDER: PRJNA961752 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24302406_1.fastq.gz	Fastqsanger.gz
	SRR24302406_2.fastq.gz	Fastqsanger.gz
	SRR24302407_1.fastq.gz	Fastqsanger.gz
	SRR24302407_2.fastq.gz	Fastqsanger.gz
	SRR24302408_1.fastq.gz	Fastqsanger.gz

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Apelin 13 breaks the immune cell route from lung to brain

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Apelin 13 breaks the immune cell route from lung to brain [scRNA-Seq]

Project description:To investigate the effect of Apelin 13 on lung in experimental autoimmune encephalomyelitis(EAE) at peak, we perform single cell RNA sequencing of the whole lung of Control, EAECont and EAE with Apelin 13 treatment(EAEA13)

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Apelin 13 breaks the immune cell route from lung to brain [RNA-Seq]

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Apelin 13 breaks the immune cell route from lung to brain [RNA-Seq]

Project description:Apelin 13 breaks the immune cell route from lung to brain [RNA-Seq]

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Apelin/APJ signaling mediated by G alpha 13 and MEF2 in endothelial cells

Project description:Evaluation of gene transcripts that are downstream of apelin/APJ signaling in HUVECs Duplicates per group, subjected to: 1) control siRNA, 2) MEF2A and MEF2C siRNA, 3) G alpha 13 siRNA, and 4) apelin and APJ siRNA

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Apelin 13 breaks the immune cell route from lung to brain

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Apelin-13 modulates the endometrial transcriptome of the domestic pig during the implantation phase of pregnancy

Project description:Apelin is a hormone secreted primarily by white adipose tissue. Recent studies have shown that adipokine and its receptor, APJ, are expressed in different reproductive tissues, including the ovary and uterus, which suggests that it may act as an important local regulator of reproductive functions. This study aimed to explore the influence of apelin on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period). We analysed samples obtained from 4 individuals (n=4). The tissue explants obtained from the uterine horns were divided into controls [without treatment] and apelin-13 (20 ng/mL) treated ones. In vitro tissue cultures were conducted for 24 hours.

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Apelin absence in endothelial cells

Project description:First, transcriptome analysis of purified CD31+ endothelial cells (ECs) from VEGF-treated sprouting embryoid bodies showed angiogenesis as the top affected category when Apelin is not present. In addition, loss of Apelin resulted in the modulation of pathways in ECs related to vasculogenesis, cell adhesion and response to hypoxia. Ingenuity Pathway Analysis (IPA) further identified VEGFR pathway as the main upstream regulator affected in endothelial cells, closely followed by the TGFβ1 and TNF pathways, all reduced in the absence of Apelin. The most inhibited genes from the VEGFR pathway in the absence of Apelin are angiogenesis-related genes. Second, transcriptome analysis of CD31+/CD105+ ECs sorted from Apelin wild-type and Apln-depleted tumors found a significant decrease in processes associated with endothelial cell proliferation and angiogenesis in ECs sorted out of Apelin-depleted tumors using IPA. Further, IPA predicted a decrease in the adhesion of granulocytes and upstream regulator analysis showed that proteins of the TGF-superfamily, Inhibin-βA and TGF-β1, as well as C/EBP-alpha, β-Catenin, ErbB2 and EGFR are predicted to be inhibited upstream regulators in ECs isolated from Apelin-depleted tumors.

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Project description:Evaluation of microRNAs that are downstream of apelin/APJ signaling in the pulmonary artery endothelial cells. Triplicates per group, subjected to: 1) control siRNA, 2) apelin siRNA, 3) APJ siRNA, 4) apelin + APJ siRNA

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