Project description:Osteoporosis, the leading cause of death among older people, is characterized by low bone mineral density (BMD) and reduced bone strength. Here, we report that miR162a, a Lycium chinense Mill-encoded microRNA, directly targets bone marrow and inhibits osteoporosis. MiR162a is stable in mice’s stomach and synthetic miR162a agomir could pass through mouse Gastrointestinal tract (GI) tract and enter the sera, bone marrow and organs.
Project description:Carassius auratus complex formula (CACF) is composed of extracts from Carassius auratus, Rhizoma dioscoreae, Lycium chinense, and Rehmannia glutinosa Libosch. These ingredients are used to treat diabetes since ancient China. Previously, CACF elicits antidiabetic effects in streptozotocin-induced diabetic mouse models under high-fat diet treatment, reduces triglyceride levels, maintains blood sugar control, and enhances insulin sensitivity. However, the effects of CACF on anti-cancer and anti-inflammation and the underlying mechanism remain unknown. In this study, we revealed that CACF could be a promising therapeutic agent with multiple functions