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Manipulating the lysine-arginine balance for successful therapy of malignant glioma by targeting lysosomal membrane integrity [I]

ABSTRACT: Manipulating the lysine-arginine balance for successful therapy of malignant glioma by targeting lysosomal membrane integrity [I]

PROVIDER: PRJNA962676 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24330257_1.fastq.gz	Fastqsanger.gz
	SRR24330257_2.fastq.gz	Fastqsanger.gz
	SRR24330258_1.fastq.gz	Fastqsanger.gz
	SRR24330258_2.fastq.gz	Fastqsanger.gz
	SRR24330259_1.fastq.gz	Fastqsanger.gz

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Manipulating the lysine-arginine balance for successful therapy of malignant glioma by targeting lysosomal membrane integrity [III]

Project description:Manipulating the lysine-arginine balance for successful therapy of malignant glioma by targeting lysosomal membrane integrity [III]

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Manipulating the lysine-arginine balance for successful therapy of malignant glioma by targeting lysosomal membrane integrity [II]

Project description:Manipulating the lysine-arginine balance for successful therapy of malignant glioma by targeting lysosomal membrane integrity [II]

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Manipulating the lysine-arginine balance for successful therapy of malignant glioma by targeting lysosomal membrane integrity [I]

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Histone arginine methyltransferase CARM1 Is Crucial for Epigenetic Regulation of Starvation-induced Autophagy

Project description:Autophagy is a highly conserved self-digestion process, essential to maintain homeostasis and viability in response to nutrient starvation. Although the components of autophagy in the cytoplasm have been well-studied, molecular basis for the epigenetic regulation of autophagy is poorly understood. Here, we identify histone arginine methyltransferase CARM1 as a critical component of autophagy. We found that nutrient starvation increased CARM1 protein level and subsequently histone H3R17 dimethylation. Genome-wide analyses reveal that CARM1 exerts transcriptional coactivator function on autophagy-related genes and lysosomal genes through TFEB. Our findings demonstrate a previously unrecognized role of CARM1-dependent histone arginine methylation as a critical nuclear event of autophagy.

2016-06-17 | GSE72901 | GEO

Lysosomal Dynamics Orchestrate Neurogenesis

Project description:Lysosomal Dynamics Orchestrate Neurogenesis

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Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection

Project description:Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic and degenerative disease in humans. Here, we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal biogenesis and autophagy. Mice and macrophages lacking cathepsin B activity had increased resistance to the cytosolic bacterial pathogen Francisella novicida. Genetic deletion or pharmacological inhibition of cathepsin B downregulated mTOR activity and prevented cleavage of the lysosomal calcium channel TRPML1. These events drove transcription of lysosomal and autophagy genes via the transcription factor TFEB, which increased lysosomal biogenesis and activation of autophagy-initiation kinase ULK1 for clearance of the bacteria. Our results identified a fundamental biological function of cathepsin B in providing a checkpoint for homeostatic maintenance of lysosome population and basic recycling functions in the cell. We used microarrays to explore the gene expression profiles differentially expressed in bone marrow-derived macrophages (BMDM) isolated from cathepsin B-/- and wild-type mice.

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ArgR1 and AhrC Mediate Arginine-Dependent Regulation of Arginine Acquisition- and Virulence Genes in the Human Pathogen Streptococcus pneumoniae

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2011-11-02 | E-GEOD-33043 | biostudies-arrayexpress

Streptococcus pneumoniae D39 wild-type grown in CDM+10 mM arginine compared to D39 wild type grown in CDM + 0.05 mM arginine

Project description:Comparison of Streptococcus pneumoniae D39 wild-type grown in CDM+10 mM arginine compared to D39 wild type grown in CDM + 0.05 mM arginine to define the genome-wide transcriptional response to arginine. Details described in Kloosterman TG and Kuipers OP. ArgR1 and AhrC Mediate Arginine-Dependent Regulation of Arginine Acquisition- and Virulence Genes in the Human Pathogen Streptococcus pneumoniae. JBC 2011 Two condition design comparison of wild type strain

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