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Ageing signatures in NSG mice

ABSTRACT: Ageing signatures in NSG mice

PROVIDER: PRJNA967331 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24440948.fastq.gz	Fastqsanger.gz
	SRR24440949.fastq.gz	Fastqsanger.gz
	SRR24440950.fastq.gz	Fastqsanger.gz
	SRR24440951.fastq.gz	Fastqsanger.gz
	SRR24440952.fastq.gz	Fastqsanger.gz

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Ageing signatures in NSG mice

Project description:Purpose: Understanding the role of an active immunesystem in ageing. Methods: Male NSG (NOD scid gamma) immunodeficient mice were maintained in normal housing condition. Islet cells were isolated at different age points and mRNA were extracted before shipping to Qiagen for analysis. Results: In NSG mice multiple of the metabolic pathways that are observed to be deregulated in ageing immunocompotent mice are infered to be sustained.

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Project description:It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male, wild-type C57BL/6J and Fmo5−/− (FMO5 KO) mice back-crossed onto the C57BL/6J background. The aim of this study was to identify metabolic signatures that are associated with ageing in both these mouse lines and to characterize the age-related differences in the metabolite profiles between the FMO5 KO mice and their wild-type counterparts at equivalent time points. We identified a range of age-related biomarkers in both urine and plasma. Some metabolites, including urinary 6-hydroxy-6-methylheptan-3-one (6H6MH3O), a mouse sex pheromone, showed similar patterns of changes with age, regardless of genetic background. Others, however, were altered only in the FMO5 KO, or only in the wild-type mice, indicating the impact of genetic modifications on mouse ageing. Elevated concentrations of urinary taurine represent a distinctive, ageing-related change observed only in wild-type mice.

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