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RNA-seq of heart healthy and heart diseased SCGs and pineal glands

ABSTRACT: RNA-seq of heart healthy and heart diseased SCGs and pineal glands

PROVIDER: PRJNA967654 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24449776.fastq.gz	Fastqsanger.gz
	SRR24449777.fastq.gz	Fastqsanger.gz
	SRR24449778.fastq.gz	Fastqsanger.gz
	SRR24449779.fastq.gz	Fastqsanger.gz
	SRR24449780.fastq.gz	Fastqsanger.gz

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heart healthy and heart diseased SCGs

Project description:heart healthy and heart diseased SCGs

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RNA-seq of heart healthy and heart diseased SCGs and pineal glands

Project description:Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently accompany cardiac disease, yet the underlying mechanism has remained enigmatic. Immunostaining of sympathetic axons in optically cleared pineal glands from humans and mice with cardiac disease revealed their substantial denervation compared to controls. Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland-innervating neurons. Depletion of macrophages in the SCG prevented disease-associated denervation of the pineal gland and restored physiological melatonin secretion. Our data identify the mechanism underlying the disturbance of diurnal rhythmicity in cardiac disease and suggest means for therapeutic intervention.

2023-07-20 | GSE231764 | GEO

RNA-seq of heart healthy and heart diseased SCGs

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RNA-seq of heart healthy and heart diseased SCGs

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single-cell RNA-seq of healthy (ctrl) and heart diseased (TAC) SCGs

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single-cell RNA-seq of healthy (ctrl) and heart diseased (TAC) SCGs

Project description:single-cell RNA-seq of healthy (ctrl) and heart diseased (TAC) SCGs

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Project description:single-nucleus RNA-seq of healthy (sham) and heart diseased (TAC) SCGs

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Transcriptome analysis of pineal glands in a mouse model of Alzheimer’s disease

Project description:The pineal gland maintains the circadian rhythm in the body by secreting the hormone melatonin. Alzheimer’s disease (AD) is the most common neurodegenerative disease. Pineal gland impairment in AD is widely observed, but no study to date has analyzed the transcriptome in the pineal glands of AD. To establish resources for the study on pineal gland dysfunction in AD, we performed a transcriptome analysis of the pineal glands of AD model mice and compared them to those of normal mice. There were diverse protein-coding RNAs, long noncoding RNAs and circular RNAs with global change in the pineal glands of AD mouse model. The analyzed data reported in this study will be an important resource for future studies to elucidate the altered physiology of the pineal gland in AD.

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Characterization of human pineal gland proteome

Project description:Pineal gland is a neuroendocrine gland located at the center of the brain. It protects the body from the effect of toxic compounds and regulates sleep-wake cycle, body temperature and sexual maturity through the secretion of melatonin. Abnormal functioning of pineal glands is known to be associated with Smith-Magenis syndrome, autism spectrum disorder, sleep disorders and Alzheimer’s disease. Characterization of pineal gland proteome will facilitate molecular level investigations on pathophysiological conditions underlying these diseases. We aimed to characterize the proteome of human pineal glands using a high resolution mass spectrometry- based approach. A total of 5,752 proteins were identified from human pineal glands in this study. Of these, 1,108 proteins contained signal peptide domain. We identified 2 novel proteins in this study, which are predicted by computational methods. In addition, a large number of proteins were uniquely identified in this study. A comprehensive list of proteins identified from human pineal glands will aid in unraveling the role of pineal glands in sleep disorders, neuropsychiatric and neurodegenerative diseases.

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