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Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis [m6A RIP]

ABSTRACT: Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis [m6A RIP]

PROVIDER: PRJNA968015 | ENA |

REPOSITORIES: ENA

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Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis [DHX58 RIP-Seq]

Project description:Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis [DHX58 RIP-Seq]

| PRJNA968014 | ENA

Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis [DHX58 RIP-Seq]

Project description:Characterized by lethal iron accumulation and lipid peroxidation, ferroptosis plays critical roles in liver injury, especially caused by ischemia/reperfusion (I/R) of hepatic inflow occlusion during liver operation. Here, we found that the excessive production of reactive oxygen species could decrease the expression of Interferon (IFN)-stimulated gene DExH-box helicase 58 (DHX58) in hepatocytes, and then promote hepatic ferroptosis, while pre-treatment using IFN-α increased DHX58 expression and prevented ferroptosis during I/R injury. Mechanistically, DHX58 with RNA-binding activity could constitutively associate the mRNA of glutathione peroxidase 4 (GPX4), a crucial ferroptosis suppressor, and then recruit the m6A reader YT521-B homology domain containing 2 (YTHDC2) to promote the translation of Gpx4 mRNA in m6A-dependent manner, thus enhancing GPX4 protein level and preventing hepatic ferroptosis.

2025-04-28 | GSE231843 | GEO

Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis [m6A RIP]

2025-04-28 | GSE231842 | GEO

Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis

Project description:Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis

| PRJNA968011 | ENA

Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis

Project description:Characterized by lethal iron accumulation and lipid peroxidation, ferroptosis plays critical roles in liver injury, especially caused by ischemia/reperfusion (I/R) of hepatic inflow occlusion during liver operation. However, the lack of effective and safe clinical precautionary measure is still the main problem in preventing hepatic ferroptosis. Here, we found that the excessive production of reactive oxygen species could decrease the expression of Interferon (IFN)-stimulated gene DExH-box helicase 58 (DHX58) in hepatocytes, and then promote hepatic ferroptosis, while pre-treatment using IFN-α increased DHX58 expression and prevented ferroptosis during I/R injury. Mechanistically, DHX58 with RNA-binding activity could constitutively associate the mRNA of glutathione peroxidase 4 (GPX4), a crucial ferroptosis suppressor, and then recruit the m6A reader YT521-B homology domain containing 2 (YTHDC2) to promote the translation of Gpx4 mRNA in m6A-dependent manner, thus enhancing GPX4 protein level and preventing hepatic ferroptosis. Therefore, we provide mechanistic evidence for the IFN-stimulated DHX58 in promoting the translation of m6A-modified Gpx4 mRNA, and suggest the promising clinical potential of IFN-α pre-treatment in the prevention of hepatic ferroptosis.

2024-05-24 | PXD042083 | Pride

Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis [scRNA-seq]

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Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis [scRNA-seq]

Project description:Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis [scRNA-seq]

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Pre-treatment of Interferon-α stimulates DHX58 to prevent hepatic ferroptosis

Project description:This SuperSeries is composed of the SubSeries listed below.

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Interleukin-17 directly stimulates tumor infiltrating Tregs to prevent cancer development [scRNA-seq]

Project description:Interleukin-17 directly stimulates tumor infiltrating Tregs to prevent cancer development [scRNA-seq]

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