Project description:Paratomy is an asexual reproductive process that occurs in annelids, flatworms and other groups. During this process, anterior structures are formed in the middle of the body, giving rise to segmented organisms, each segment being called a zooid. Once formed, the zooids detach and form new organisms. Using RNAseq of worms prior to zooid formation and with two zooids, we search for genes that are differentially expressed and may be related to the control of this process in the flatworm Stenostomum leucops. Several signaling pathways showed differential expression, including MAPK/ERK, PI3K-Akt, Wnt, TGFb, mTOR, FoxO and others. Forty-five genes were found to be particularly significant because they are differentially expressed and play an important role in the development of other flatworms. These include ERK, MKP, JNK, PI3K, PTEN, β -catenin, FoxO, Sufu, GH and others. The results suggest some similarities in gene regulation between paratomy and regeneration observed in other flatworms after fission or amputation. In worms without zooids, pathways required for cell proliferation, differentiation of cells into multiple cell lineages and determination of the body axis are activated. In worms with 2 zooids, genes involved in cell growth and apoptosis are activated. Activation of genes involved in neoblast proliferation and maintenance appears to occur at both stages.

| S-EPMC11589783 | biostudies-literature

Project description:Organisation EGAO00000000974

| EGAO00000000974 | EGA

Genome sequence of the soil bacterium Saccharomonospora azurea type strain (NA-128(T)).

Project description:Saccharomonospora azurea Runmao et al. 1987 is a member of the genus Saccharomonospora, which is in the family Pseudonocardiaceae and thus far poorly characterized genomically. Members of the genus Saccharomonospora are of interest because they originate from diverse habitats, such as leaf litter, manure, compost, the surface of peat, and moist and over-heated grain, and may play a role in the primary degradation of plant material by attacking hemicellulose. Next to S. viridis, S. azurea is only the second member in the genus Saccharomonospora for which a completely sequenced type strain genome will be published. Here we describe the features of this organism, together with the complete genome sequence with project status 'Improved high quality draft', and the annotation. The 4,763,832 bp long chromosome with its 4,472 protein-coding and 58 RNA genes was sequenced as part of the DOE funded Community Sequencing Program (CSP) 2010 at the Joint Genome Institute (JGI).

| S-EPMC3387790 | biostudies-literature

Project description:Microbiome interaction with Stenostomum leucops (Platyhelminthe, Catenulide).

| PRJNA789233 | ENA