Dataset Information

Koumiss

ABSTRACT: Koumiss Metagenome

PROVIDER: PRJNA971349 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24574900_1.fastq.gz	Fastqsanger.gz
	SRR24574900_2.fastq.gz	Fastqsanger.gz
	SRR24574901_1.fastq.gz	Fastqsanger.gz
	SRR24574901_2.fastq.gz	Fastqsanger.gz
	SRR24574902_1.fastq.gz	Fastqsanger.gz

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Project description:<p>Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite capable of infecting nearly all warm-blooded animals, including humans, with epidemiological studies indicating remarkably high global infection. However, due to its complex life cycle, no effective vaccine has been widely applied. Studies have revealed that many pathogen-induced infections can be mitigated by regulating the intestinal microenvironment. Probiotics, recognized as food-safe microbial agents for gut ecosystem modulation, have become a hotspot in developing novel interventions. Building upon our previous discovery that koumiss alleviates T. gondii infection in mice, this study successfully isolated Lactiplantibacillus plantarum HB (L. plantarum HB)-the most efficacious strain identified through screening from this koumiss, and further investigated its alleviative efficacy and mechanisms against toxoplasmosis. Results demonstrated that L. plantarum HB significantly ameliorated ileal inflammation and neuroinflammation, accompanied by marked reductions in parasite burden in multiple organs and brain tissues, while uncovering dynamic cytokine alterations during infection progression. Correlation analyses established direct associations between these alleviate outcomes and L. plantarum HB-mediated gut microbiota restructuring: acute-phase mitigation of ileal inflammation correlated with upregulated Akkermansia and downregulated Escherichia abundances, while chronic-phase neuroprotection was associated with enriched Lactobacillaceae and Bifidobacterium. Whole-genome sequencing revealed genetic determinants potentially underlying L. plantarum HB's functional, including carbohydrate metabolism and amino acid biosynthesis. Metabolomic profiling further elucidated alleviate mechanisms involving protein digestion and absorption, D-amino acid metabolism, and histidine metabolic regulation. These findings advance the understanding of probiotic applications and provide novel insights into mitigating toxoplasmosis.</p>

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Koumiss

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