Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Dominance of M1UK clade among Dutch M1 Streptococcus pyogenes

PROVIDER: PRJNA971538 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24502953_1.fastq.gz	Fastqsanger.gz
	SRR24502953_2.fastq.gz	Fastqsanger.gz
	SRR24502954_1.fastq.gz	Fastqsanger.gz
	SRR24502954_2.fastq.gz	Fastqsanger.gz
	SRR24502955_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 90

Similar Datasets

Streptococcus pyogenes isolates in the Netherlands in 2019

Project description:Dominance of M1UK clade among invasive M1 Streptococcus pyogenes isolates in the Netherlands in 2019

| PRJEB38751 | ENA

Characterisation of the genetic mutation driving enhanced superantigen SpeA expression in Streptococcus pyogenes M1UK (initial)

Project description:A new variant of group A Streptococcus (GAS) serotype M1 (designated ‘M1UK’) has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor GAS ‘M1global’ and M1UK clones can be differentiated by 27 SNPs and 4 indels, yet the mechanism for speA upregulation is unknown. Here we investigate the previously unappreciated expansion of M1UK in Australia, now isolated from the majority of serious infections caused by serotype M1 GAS. M1UK sub-lineages circulating in Australia also contain a novel toxin repertoire associated with epidemic scarlet fever causing GAS in Asia. A single SNP in the M1UK tmRNA gene ssrA drives enhanced SpeA superantigen expression as a result of ssrA terminator readthrough in the M1UK lineage. This represents a new paradigm of toxin expression and urges enhanced international surveillance.

2023-01-30 | GSE212238 | GEO

Characterisation of the genetic mutation driving enhanced superantigen SpeA expression in Streptococcus pyogenes M1UK (second SP1448)

2023-01-30 | GSE212242 | GEO

Characterisation of the genetic mutation driving enhanced superantigen SpeA expression in Streptococcus pyogenes M1UK (second SP1380)

2023-01-30 | GSE212241 | GEO

Characterisation of the genetic mutation driving enhanced superantigen SpeA expression in Streptococcus pyogenes M1UK (second 5448)

2023-01-30 | GSE212239 | GEO

RNA-seq analysis of a Streptococcus pyogenes mutant lacking the eukaryote-type ser/thr phosphatase (SP-STP)

Project description:We report the mRNA expression profile of Streptococcus pyogenes Type M1 strain M1T15448-derived mutant lacking Serine threonine phosphatase.

2016-10-29 | GSE74541 | GEO

RNA-seq analysis of a Streptococcus pyogenes mutant lacking the eukaryote-type ser/thr kinase (SP-STK)

Project description:We report the mRNA expression profile of Streptococcus pyogenes Type M1 strain M1T15448-derived mutant lacking eukaryote-type Serine threonine kinase.

2016-11-02 | GSE74590 | GEO

RNA-seq-based transcriptome analysis of a Streptococcus pyogenes mutant expressing cytoplasmically restricted enolase.

Project description:We report the mRNA expression profile of Streptococcus pyogenes Type M1 strain M1T15448-derived mutant lacking eukaryote-type Serine threonine kinase.

2016-11-02 | GSE74638 | GEO

Streptococcus pyogenes (GAS) membrane vesicles (MVs) and membranes LC-MSMS

Project description:Proteomics characterisation of membrane vesicles (MV) and corresponding membranes derived from Streptococcus pyogenes M1 (clinical isolate ISS3348) grown to late-logarithmic phase in THB media.

2016-10-18 | PXD005167 | Pride

non-M1 covRS-intact and -mutant GAS vs M1 controls

Project description:Microarray was performed on RNA extracted from mid-logarithmic phase in vitro grown non-M1 Streptococcus pyogenes isolates, with either intact or mutant covRS operons. These isolates were compared with corresponding M1 covRS intact and mutant forms to link the expression prolfiles of these non-M1 isolates with invasive pathogenesis.

2010-08-27 | GSE23825 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data