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Comparative single-cell analyses identify shared and divergent features of human and mouse kidney development [mouse snATAC-seq]

ABSTRACT: Comparative single-cell analyses identify shared and divergent features of human and mouse kidney development [mouse snATAC-seq]

PROVIDER: PRJNA972294 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24542230_1.fastq.gz	Fastqsanger.gz
	SRR24542230_2.fastq.gz	Fastqsanger.gz
	SRR24542231_1.fastq.gz	Fastqsanger.gz
	SRR24542231_2.fastq.gz	Fastqsanger.gz
	SRR24542232_1.fastq.gz	Fastqsanger.gz

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Comparative single-cell analyses identify shared and divergent features of human and mouse kidney development [mouse snATAC-seq]

Project description:Mammalian kidneys maintain fluid homeostasis through the cellular activity of nephrons and the conjoined collecting system. Each epithelial network originates from distinct progenitor cell populations that reciprocally interact during development. To extend our understanding of human and mouse kidney development, we profiled chromatin organization (ATAC-seq) and gene expression (RNA-seq) in developing human and mouse kidneys. Data were analyzed at a species level and then integrated into a common, cross-species multimodal data set. Comparative analysis of cell types and developmental trajectories identified conserved and divergent features of chromatin organization and linked gene activity, revealing species- and cell-type specific regulatory programs. Identification of human-specific enhancer regions linked through GWAS studies to kidney disease highlights the potential of developmental modeling to provide clinical insight.

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snATAC-seq data from single cell multiomics (paired snRNA-seq+snATAC-seq) of human colorectal cancer liver metastatic samples

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Comparative single-cell analyses identify shared and divergent features of human and mouse kidney development

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