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Genome-wide analysis of DNA methylation in pseudomyxoma peritonei originated from appendiceal cancer

ABSTRACT: Genome-wide analysis of DNA methylation in pseudomyxoma peritonei originated from appendiceal cancer

PROVIDER: PRJNA973579 | ENA |

REPOSITORIES: ENA

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Single-cell RNA-seq profiling of Pseudomyxoma Peritonei

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Genome-wide analysis of DNA methylation in pseudomyxoma peritonei originated from appendiceal cancer

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Project description:The purpose of this study is to evaluate gene expression changes and identify characteristics in patients with Pseudomyxoma Peritonei (PMP). We analyzed RNA-seq data from 34 formalin-fixed paraffin-embedded (FFPE) samples, including 25 PMPs (validation cohort), to identify gene signatures associated with the development of PMP. We confirmed protein expression levels using a tissue microarray (TMA) cohort of PMP patients. Through analyzing the differences in gene expression between normal tissues and PMP, we identified statistically significant gene groups, and confirmed the biological functions and pathways associated with these gene groups.

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Project description:Cell of origin and expression profiles of pseudomyxoma peritonei derived from the appendix

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