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Effecto of ROS (H2O2) on undifferentiated NSC

ABSTRACT: Effecto of ROS (H2O2) on undifferentiated NSC

PROVIDER: PRJNA975183 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24687657_1.fastq.gz	Fastqsanger.gz
	SRR24687657_2.fastq.gz	Fastqsanger.gz
	SRR24687658_1.fastq.gz	Fastqsanger.gz
	SRR24687658_2.fastq.gz	Fastqsanger.gz
	SRR24687659_1.fastq.gz	Fastqsanger.gz

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Effect of ROS (H2O2) on undifferentiated NSC

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Effecto of ROS (H2O2) on undifferentiated NSC

Project description:Realease of reactiv oxigen species, such as H2O2, has been observed during inflammatory processes but is also a physiological side product of metabolism. We have observed that differentiation of neural progenitor cells (NPC) is affected by H2O2 exposure. We here asses the transcriptional drivers of the phenotypical changes NPCs undergo during differentiation in response to H2O2.

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Effect of ROS (H2O2) on undifferentiated NSC

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Project description:In this study, we generated wildtype H9 hESC derived cardiomyocytes (CM) and neural stem cells (NSC) by in vitro differentiation. Global gene expression profiles were compared among undifferentiated H9 hESC and the derived CM and NSC. Comparison of global gene expression profiles of undifferentiated H9 hESC and the derived CM and NSC populations.

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Project description:Reactive oxygen species (ROS) are key signalling molecules that regulate growth and development and coordinate responses to biotic and abiotic stresses. ROS homeostasis is controlled through a complex network of ROS production and scavenging enzymes. Recently, the first genes involved in ROS perception and signal transduction have been identified and, currently, we are facing the challenge to uncover the other players within the ROS regulatory gene network. The specificity of ensuing cellular responses depends on the type of ROS and their subcellular production sites. Various experimental systems, including catalase-deficient plants, in combination with genome-wide expression studies demonstrated that increased hydrogen peroxide (H2O2) levels significantly affect the transcriptome of plants and are capable of launching both defence responses and cell death events. We used microarrays to assess differential gene expression provoked by H2O2 from plastid or peroxisomal origin, respectively.

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