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Glycolytic shift during West Nile virus infection provides new therapeutic opportunities

ABSTRACT: Glycolytic shift during West Nile virus infection provides new therapeutic opportunities

PROVIDER: PRJNA975479 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24705800_1.fastq.gz	Fastqsanger.gz
	SRR24705800_2.fastq.gz	Fastqsanger.gz
	SRR24709800_1.fastq.gz	Fastqsanger.gz
	SRR24709800_2.fastq.gz	Fastqsanger.gz
	SRR24705801_1.fastq.gz	Fastqsanger.gz

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Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Brain]

Project description:Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Brain]

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Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Cerebellum]

Project description:Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Cerebellum]

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Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [2DG and DGA compounds]

Project description:Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [2DG and DGA compounds]

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Glycolytic shift during West Nile virus infection provides new therapeutic opportunities

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-09-27 | GSE233218 | GEO

Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Cerebellum]

Project description:To investigate the in vivo metabolic changes during WNV infection in a mouse model, we infected mice with WNV NY99 to compare to uninfected (mock) mice. We also use two compounds targeting energetic metabolism to analysed their effects on WNV infection We then performed gene expression profiling analysis using data obtained from RNA-seq from infected vs uninfected mice and treated mice.

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Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [Brain]

2023-09-27 | GSE233216 | GEO

Glycolytic shift during West Nile virus infection provides new therapeutic opportunities.

Project description:BackgroundViral rewiring of host bioenergetics and immunometabolism may provide novel targets for therapeutic interventions against viral infections. Here, we have explored the effect on bioenergetics during the infection with the mosquito-borne flavivirus West Nile virus (WNV), a medically relevant neurotropic pathogen causing outbreaks of meningitis and encephalitis worldwide.ResultsA systematic literature search and meta-analysis pointed to a misbalance of glucose homeostasis in the central nervous system of WNV patients. Real-time bioenergetic analyses confirmed upregulation of aerobic glycolysis and a reduction of mitochondrial oxidative phosphorylation during viral replication in cultured cells. Transcriptomics analyses in neural tissues from experimentally infected mice unveiled a glycolytic shift including the upregulation of hexokinases 2 and 3 (Hk2 and Hk3) and pyruvate dehydrogenase kinase 4 (Pdk4). Treatment of infected mice with the Hk inhibitor, 2-deoxy-D-glucose, or the Pdk4 inhibitor, dichloroacetate, alleviated WNV-induced neuroinflammation.ConclusionsThese results highlight the importance of host energetic metabolism and specifically glycolysis in WNV infection in vivo. This study provides proof of concept for the druggability of the glycolytic pathway for the future development of therapies to combat WNV pathology.

| S-EPMC10537838 | biostudies-literature

Glycolytic shift during West Nile virus infection provides new therapeutic opportunities [2DG and DGA compounds]

Project description:To investigate the in vivo metabolic changes during WNV infection in a mouse model, we infected mice with WNV NY99 to compare to uninfected (mock) mice. We also use two compounds targeting energetic metabolism to analyze their effects on WNV infection We then performed gene expression profiling analysis using data obtained from RNA-seq from infected vs uninfected mice and treated mice.

2023-09-27 | GSE233215 | GEO

scRNA-seq of peripheral blood from West Nile Virus-infected patients

Project description:We profile the peripheral blood of patients infected with West Nile Virus with divergent disease-trajectories (West Nile Encephalitis, West Nile Fever, and asymptomatic) during relatively acute infection and at a convalescent timepoint (~90-days later) using single-cell RNA sequencing in an effort to uncover determinants of disease progression and flesh out the landscape of infection. In the blood of the infected patients, stratified cell-states involved in acute viral infection resolve into more homogenous states at the follow-up blood draws, A dramatic shared transcriptional shift between the primary blood-draws during acute infection and the 90-day follow-ups in all observed compartments allows us to highlight multiple cell-type and cell-state-specific patterns of gene expression.

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Project description:West Nile virus overview

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