Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in Luminal A breast cancer

ABSTRACT: Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in Luminal A breast cancer

PROVIDER: PRJNA975550 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24709200_1.fastq.gz	Fastqsanger.gz
	SRR24709200_2.fastq.gz	Fastqsanger.gz
	SRR24709201_1.fastq.gz	Fastqsanger.gz
	SRR24709201_2.fastq.gz	Fastqsanger.gz
	SRR24709202_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 172

Similar Datasets

Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in Luminal A breast cancer

Project description:To investigate circadian clocks in human breast tumors, 43 pairs of human samples (tumor and matched normal breast tissues from the same patient) were collected to run bulk-RNAseq, including 29 pairs of Luminal A, 3 pairs of Luminal B, 2 pairs of HER2 and 9 pairs of Triple-negative breast cancer

2024-01-26 | GSE233242 | GEO

Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer.

Project description:Studies in shift workers and model organisms link circadian disruption to breast cancer. However, molecular circadian rhythms in noncancerous and cancerous human breast tissues and their clinical relevance are largely unknown. We reconstructed rhythms informatically, integrating locally collected, time-stamped biopsies with public datasets. For noncancerous breast tissue, inflammatory, epithelial-mesenchymal transition (EMT), and estrogen responsiveness pathways show circadian modulation. Among tumors, clock correlation analysis demonstrates subtype-specific changes in circadian organization. Luminal A organoids and informatic ordering of luminal A samples exhibit continued, albeit dampened and reprogrammed rhythms. However, CYCLOPS magnitude, a measure of global rhythm strength, varied widely among luminal A samples. Cycling of EMT pathway genes was markedly increased in high-magnitude luminal A tumors. Surprisingly, patients with high-magnitude tumors had reduced 5-y survival. Correspondingly, 3D luminal A cultures show reduced invasion following molecular clock disruption. This study links subtype-specific circadian disruption in breast cancer to EMT, metastatic potential, and prognosis.

| S-EPMC10873596 | biostudies-literature

Clock

Project description:Rattus norvegicus Clock, clock circadian regulator [Source:RGD Symbol;Acc:620271], is differentially expressed in 35 experiment(s);

| ENSRNOG00000002175 | ExpressionAtlas

Clock

Project description:Rattus norvegicus Clock, clock circadian regulator [Source:RGD Symbol;Acc:620271], is expressed in 6 baseline experiment(s);

| ENSRNOG00000002175 | ExpressionAtlas

CLOCK

Project description:Monodelphis domestica CLOCK, clock circadian regulator [Source:NCBI gene;Acc:100017022], is expressed in 2 baseline experiment(s);

| ENSMODG00000020678 | ExpressionAtlas

CLOCK

Project description:Sus scrofa CLOCK, clock circadian regulator [Source:VGNC Symbol;Acc:VGNC:86774], is expressed in 2 baseline experiment(s);

| ENSSSCG00000008909 | ExpressionAtlas

CLOCK

Project description:Macaca mulatta CLOCK, clock circadian regulator [Source:VGNC Symbol;Acc:VGNC:71262], is expressed in 2 baseline experiment(s);

| ENSMMUG00000001919 | ExpressionAtlas

CLOCK

Project description:Homo sapiens CLOCK, clock circadian regulator [Source:HGNC Symbol;Acc:HGNC:2082], is differentially expressed in 149 experiment(s);

| ENSG00000134852 | ExpressionAtlas

CLOCK

Project description:Oryctolagus cuniculus CLOCK, clock circadian regulator [Source:HGNC Symbol;Acc:HGNC:2082], is expressed in 1 baseline experiment(s);

| ENSOCUG00000022350 | ExpressionAtlas

CLOCK

Project description:Homo sapiens CLOCK, clock circadian regulator [Source:HGNC Symbol;Acc:HGNC:2082], is expressed in 45 baseline experiment(s);

| ENSG00000134852 | ExpressionAtlas