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Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [bulkRNASeq]

ABSTRACT: Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [bulkRNASeq]

PROVIDER: PRJNA976056 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24731600.fastq.gz	Fastqsanger.gz
	SRR24731601.fastq.gz	Fastqsanger.gz
	SRR24731602.fastq.gz	Fastqsanger.gz
	SRR24731603.fastq.gz	Fastqsanger.gz
	SRR24731604.fastq.gz	Fastqsanger.gz

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Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve

Project description:Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve

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Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [bulkRNASeq]

Project description:Organ injury stimulates the formation of new capillaries to restore blood supply raising questions about the potential contribution of neoangiogenic vessel architecture to the healing process. With single-cell mapping we resolved the properties of endothelial cells that organize a polarized scaffold at the repair site of lesioned peripheral nerves. Transient reactivation of an embryonic guidance program is required to orient neovessels across the wound. Manipulation of this structured angiogenic response through genetic and pharmacological targeting of Plexin-D1/VEGF pathways within an early window of repair has long-term impact on configuration of the nerve stroma. Neovessels direct nerve-resident mesenchymal cells to mold a provisionary fibrotic scar by assembling an orderly system of stable barrier compartments that channel regenerating nerve fibers and shield them from the persistently leaky vasculature. Thus, guided and balanced repair angiogenesis enables the construction of a “bridge” microenvironment conducive for axon regrowth and homeostasis of the regenerated tissue.

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Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Pdgfrb]

Project description:Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Pdgfrb]

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Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Cdh5]

Project description:Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Cdh5]

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Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Pdgfrb]

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Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve

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