Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq4]

ABSTRACT: CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq4]

PROVIDER: PRJNA976308 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24742194.fastq.gz	Fastqsanger.gz
	SRR24742195.fastq.gz	Fastqsanger.gz
	SRR24742196.fastq.gz	Fastqsanger.gz
	SRR24742197.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology

Project description:CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology

| PRJNA856707 | ENA

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [microarray]

Project description:CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [microarray]

| PRJNA856683 | ENA

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq3]

Project description:CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq3]

| PRJNA940513 | ENA

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq1]

Project description:CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq1]

| PRJNA856711 | ENA

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq2]

Project description:CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq2]

| PRJNA856710 | ENA

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-08-16 | GSE207702 | GEO

CXCR6 orchestrates brain CD8<sup>+</sup> T cell residency and limits mouse Alzheimer's disease pathology.

Project description:Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by innate immune-mediated inflammation, but functional and mechanistic effects of the adaptive immune system remain unclear. Here we identify brain-resident CD8+ T cells that coexpress CXCR6 and PD-1 and are in proximity to plaque-associated microglia in human and mouse AD brains. We also establish that CD8+ T cells restrict AD pathologies, including β-amyloid deposition and cognitive decline. Ligand-receptor interaction analysis identifies CXCL16-CXCR6 intercellular communication between microglia and CD8+ T cells. Further, Cxcr6 deficiency impairs accumulation, tissue residency programming and clonal expansion of brain PD-1+CD8+ T cells. Ablation of Cxcr6 or CD8+ T cells ultimately increases proinflammatory cytokine production from microglia, with CXCR6 orchestrating brain CD8+ T cell-microglia colocalization. Collectively, our study reveals protective roles for brain CD8+ T cells and CXCR6 in mouse AD pathogenesis and highlights that microenvironment-specific, intercellular communication orchestrates tissue homeostasis and protection from neuroinflammation.

| S-EPMC11102766 | biostudies-literature

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [microarray]

Project description:Our study reveals a previously unappreciated role for microenvironment-specific, inter-cellular crosstalk between CD8+ T cells and microglia in delaying neurodegenerative disease development

2023-08-17 | GSE207682 | GEO

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq4]

2023-08-17 | GSE233463 | GEO

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq2]

2023-08-17 | GSE207701 | GEO