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DNA dioxygenase Tet2 regulates liver regeneration after partial hepatectomy.

ABSTRACT: DNA dioxygenase Tet2 regulates liver regeneration after partial hepatectomy.

PROVIDER: PRJNA976469 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24743000_1.fastq.gz	Fastqsanger.gz
	SRR24743000_2.fastq.gz	Fastqsanger.gz
	SRR24743001_1.fastq.gz	Fastqsanger.gz
	SRR24743001_2.fastq.gz	Fastqsanger.gz
	SRR24743002_1.fastq.gz	Fastqsanger.gz

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DNA dioxygenase Tet2 regulates liver regeneration after partial hepatectomy [dataset1]

Project description:DNA dioxygenase Tet2 regulates liver regeneration after partial hepatectomy [dataset1]

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DNA dioxygenase Tet2 regulates liver regeneration after partial hepatectomy [dateset2]

Project description:DNA dioxygenase Tet2 regulates liver regeneration after partial hepatectomy [dateset2]

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DNA dioxygenase Tet2 regulates liver regeneration after partial hepatectomy [dateset2]

Project description:To investigate how liver macrophages regulate liver regeneration after partial hepatectomy, we isolate the macrophages 0, 24, and 48h after partial hepatectomy(PHx). We performed gene expression profiling analysis using data obtained from RNA-seq of liver macrophages 0,24,48h after partial hepatectomy.

2025-05-21 | GSE233515 | GEO

Characterization of hepatic gene expression during liver regeneration in response to partial hepatectomy

Project description:This SuperSeries is composed of the following subset Series: GSE20425: Hepatic gene expression during liver regeneration in response to partial hepatectomy: early time points (0.5h,1h,2h,4h) GSE20426: Hepatic gene expression during liver regeneration in response to partial hepatectomy: late time points (24h, 38h, 48h) Refer to individual Series

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Expression data from rat hepatocyte during liver regeneration after partial hepatectomy

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Expression data from rat hepatocyte during liver regeneration after partial hepatectomy

Project description:The recovery of liver mass is mainly mediated by proliferation and enlargement of hepatocytes after partial hepatectomy. Studying the gene expression profiles of hepatocytes after partial hepatectomy will be helpful in exploring the mechanism of liver regeneration. We used microarrays to further highlight the regulatory role of hepatocyte in liver regeneration at gene transcription level. Rat liver regeneration after partial hepatectomy (PH) is a good model to study the regulation of cell proliferation. We isolated hepatocytes from regenerating liver at 9 time points (2, 6, 12,24, 30, 36, 72, 120, and 168h) after PH and measured gene expression profiles of hepatocytes from 2h to 168h with rat Genome 230 2.0 gene chip. Each sample corresponding to one time point was hybridized onto one array. The experiment was repeated 3 times for each time point. In total, 10 time points were measured and 0h was used control group. After careful quality control analyses of each chip, Affymetrix GCOS 2.0 software was used to analyze the data. The relevance of gene expression profiles and biological processes was analyzed by bioinformatics and systems biology.

2014-02-28 | E-GEOD-55434 | biostudies-arrayexpress

DNA dioxygenase Tet2 regulates liver regeneration after partial hepatectomy [dataset1]

Project description:To investigate how Tet2 inhibitor (Bobcat339 hydrochloride or 4-Octyl Itaconate) affected the function of primary hepatocytes, we treated peritoneal macrophages with Bobcat339 hydrochloride，4-Octyl Itaconate, and DMSO. We performed gene expression profiling analysis using data obtained from RNA-seq of primary hepatocytes with three treatments

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ACUTE BLEEDING AND STORED RED BLOOD CELLS TRANSFUSION ATTENUATES LIVER REGENERATION FOLLOWING PARTIAL HEPATECTOMY

Project description:Our aim was to study the impact of bleeding and red blood cell (RBC) resuscitation on liver regeneration. We assessed the impact of RBC storage time on liver regeneration following 50% partial hepatectomy (PHx) in rats, and explored possible contributing molecular mechanisms using immunohistochemistry, RNA-Seq, and macrophage depletion.

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Expression data from rat liver tissue during liver regeneration after partial hepatectomy.

Project description:The liver has extraordinary powers of regeneration after partial hepatectomy (PH). Changes of gene expression play a key role in cell proliferation and differentiation during liver regeneration (LR). To understand the molecular mechanisms underlying LR, this study was designed to assess the changes of rat hepatic gene expression in a timely manner. We used microarrays to further highlight the regulatory role of rat liver tissue in liver regeneration at gene transcription level.

2014-12-02 | GSE63742 | GEO

Transcription profiling of mouse liver regeneration after partial hepatectomy

Project description:The goal of this study is to obtain an expression profile of regenerating mouse livers. We used microarray analysis to study the gene groups coordinately expressed temporally during mouse a liver regeneration. One of the syn-expression groups that showed a sharp rise in gene expression immediately after hepatectomy contains a set pancreatic exocrine genes. The syn-expression profile of pancreatic genes and the pancreatic-specific transcription factors Ptf1a and Ipf1 was confirmed using real-time PCR. Electron microscopic examination showed the presence of morphological features reminiscent of pancreatic acinar cells with the presence of characteristic zymogen granules and ER organization. These results indicate that there is a transient liver-to-pancreas transdifferentiation event at the beginning of liver regeneration. A strong coordinated up-regulation of pancreatic genes was found to accompany the injury response in the pancreas, suggesting a compensatory mechanism for pancreatic functions. There seems to be a relationship between the induction of pancreatic genes and acute phase response at the beginning of liver regeneration. Experiment Overall Design: Total RNA was extracted from livers of mice recovered at Experiment Overall Design: various hours after partial hepatectomy (PHx 4h, 8h, 12h, 36h, Experiment Overall Design: 48h, 72h). We grouped livers of four to six mice together for Experiment Overall Design: RNA extraction. Genes showed differentially up- or downregulated Experiment Overall Design: by two-fold with respect to the normal mouse livers Experiment Overall Design: were identified using GeneSpring software version 7.2 (Silicon Experiment Overall Design: Genetics, Agilent Technologies).

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