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Pre-determined diversity in resistant fates emerges from homogenous cells after anti-cancer drug treatment (single-cell data)

ABSTRACT: Pre-determined diversity in resistant fates emerges from homogenous cells after anti-cancer drug treatment (single-cell data)

PROVIDER: PRJNA977878 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24770531_1.fastq.gz	Fastqsanger.gz
	SRR24770531_2.fastq.gz	Fastqsanger.gz
	SRR24770532_1.fastq.gz	Fastqsanger.gz
	SRR24770532_2.fastq.gz	Fastqsanger.gz
	SRR24770533_1.fastq.gz	Fastqsanger.gz

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Pre-determined diversity in resistant fates emerges from homogenous cells after anti-cancer drug treatment

Project description:Pre-determined diversity in resistant fates emerges from homogenous cells after anti-cancer drug treatment

| PRJNA976924 | ENA

Pre-determined diversity in resistant fates emerges from homogenous cells after anti-cancer drug treatment

Project description:Even amongst genetically identical cancer cells, therapy resistance often only emerges from a very small subset of those cells. Much effort has gone into uncovering the molecular differences in rare individual cells in the initial population that may allow certain cells to become therapy resistant; however, comparatively little is known about variability in the resistant outcomes themselves. Here, we develop and apply FateMap, a framework that combines DNA barcoding with single-cell RNA sequencing to reveal the fates of hundreds of thousands of clones exposed to anti-cancer therapies. We show that resistant clones emerging from single-cell-derived cancer cells adopt molecularly, morphologically, and functionally distinct fate types. These different resistant types are largely predetermined by molecular differences between cells before addition of drug and not by extrinsic cell-specific microenvironmental factors. Changes in dose and kind of drug can, however, switch the resistant fate type of an initial cell, even resulting in the generation and elimination of certain fate types. Diversity in resistant fates was observed across several single-cell-derived cancer cell lines and types treated with a variety of drugs. Cell fate diversity as a result of variability in intrinsic cell states may be a generic feature of response to external cues.

2023-05-31 | GSE233622 | GEO

Pre-determined diversity in resistant fates emerges from homogenous cells after anti-cancer drug treatment (single-cell data)

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Project description:Pre-determined diversity in resistant fates emerges from homogenous cells after anti-cancer drug treatment

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Expression Profile of Homogenous Bone Marrow Stromal Stem Cell Clones

Project description:The role of bone marrow stromal cells in angiogenesis and tissue regeneration has previously been assessed by the use of heterogenous populations. This experiment is designed to assess the angiogenic potential of homogenous, well characterized clones and to provide gene expression profiling for these clones. Keywords: other

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Immune Resistance Emerges from Tumor-Initiating Stem Cells

Project description:Immune Resistance Emerges from Tumor-Initiating Stem Cells

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Characterization of the self-organization of primitive streak and neuroectoderm fates

Project description:Characterization of the signaling requirements to determine primitive streak and neuroectoderm fates in mouse embryonic stem cells.

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Project description:We have used ATAC-seq to track cell state changes that occur during the differentiation of mouse embryonic stem cells to defined neural progenitor fates. We have performed ATAC-seq every 24 hours in cells en route to 3 distinct neural progenitors fates, anterior, hindbrain and spinal cord. This has allowed us to define how cells transition to a neural state, based on their enhancer usage. We identified regions distinct to different anterior-posterior neural progenitors, and validated their relevance by performing in vivo ATAC-seq on neural progenitors isolated from different axial levels of mouse embryos.

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