Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell level characterization of Cdh11 deficiency-induced changes in pancreatic cancer

ABSTRACT: Single cell level characterization of Cdh11 deficiency-induced changes in pancreatic cancer

PROVIDER: PRJNA978564 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR24796081.fastq.gz	Fastqsanger.gz
	SRR24796083.fastq.gz	Fastqsanger.gz
	SRR24796084.fastq.gz	Fastqsanger.gz
	SRR24796085.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 5

Similar Datasets

Single cell level characterization of Cdh11 deficiency-induced changes in pancreatic cancer

Project description:Cadherin 11 (Cdh11), a cell-to-cell adhesion molecule, has been suggested to promote tumor growth and immunosuppression in PDAC, and Cdh11 inhibition significantly extended survival in mice with PDAC. However, the mechanisms by which Cdh11 deficiency influences PDAC progression and anti-tumor immune responses has yet to be fully elucidated. To investigate Cdh11-deficiency induced changes in PDAC tumor microenvironment (TME), we crossed p48-Cre; LSL-KrasG12D/+; LSL-Trp53R172H/+ (KPC) mice with Cdh11+/- mice and performed single-cell RNA sequencing (scRNA-seq) of the non-immune (CD45-) and immune (CD45+) compartment of KPC tumor bearing Cdh11 proficient (KPC-Cdh11+/+) and Cdh11 deficient (KPC-Cdh11+/-) mice.

2025-05-01 | GSE233915 | GEO

Single cell level characterization of injury-induced immune changes in MRL/MpJ knee joints

Project description:Single cell level characterization of injury-induced immune changes in MRL/MpJ knee joints

| PRJNA909167 | ENA

Characterization of molecular changes associated with complement factor B deficiency in the mouse auditory nerve

Project description:Characterization of molecular changes associated with complement factor B deficiency in the mouse auditory nerve

| PRJNA756231 | ENA

Comprehensive characterization of hepatic inflammatory changes in a mouse model of alpha-1 antitrypsin deficiency

Project description:Comprehensive characterization of hepatic inflammatory changes in a mouse model of alpha-1 antitrypsin deficiency

| PRJNA851584 | ENA

Transcriptomic characterization of Malus domestica response to Fe and P deficiency

Project description:Transcriptomic characterization of Malus domestica response to iron and phosphorus deficiency.

2019-05-01 | GSE122554 | GEO

Molecular Characterization of auditory nerve with Versican deficiency

Project description:Molecular Characterization of auditory nerve with Versican deficiency

| PRJNA503256 | ENA

Microbial changes in early pancreatic cancer progression

Project description:Microbial changes in early pancreatic cancer progression

| PRJEB33219 | ENA

Proteogenomic characterization of pancreatic neuroendocrine tumor

Project description:To characterize pancreatic neuroendocrine tumor at protein level, we performed mass spectromery-based proteome analysis using clinical FFPE tissue samples.

2024-07-10 | PXD034571 | Pride

ARID1A deficiency promotes pancreatic tumorigenesis by reducing KRAS-induced senescence (ATAC-Seq)

Project description:ARID1A is one of the most frequently mutated epigenetic regulators in a wide spectrum of cancers. In this study, we identified the anti-senescence effect of ARID1A deficiency in the progression of pancreatic intraepithelial neoplasia (PanIN) by profiling the transcriptome of individual PanINs in the mouse model. Interestingly, we found that ARID1A deficiency activates the transcription of Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), which play essential roles in attenuating the senescence by significantly reducing reactive oxygen species (ROS) induced by oncogenic KRAS. Our findings further suggest that ALDH could be considered as a potential adjuvant target for prevention and treatment of pancreatic cancer.

2021-06-06 | GSE160440 | GEO

Iron Deficiency Triggered Transcriptome Changes in Bread Wheat

Project description:Iron Deficiency Triggered Transcriptome Changes in Bread Wheat

| PRJNA680330 | ENA