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Decoding the gene promoters binding with BRD3 in LPS-primed THP1 monocytes

ABSTRACT: Decoding the gene promoters binding with BRD3 in LPS-primed THP1 monocytes

PROVIDER: PRJNA980218 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24831177.fastq.gz	Fastqsanger.gz
	SRR24831178.fastq.gz	Fastqsanger.gz
	SRR24831179.fastq.gz	Fastqsanger.gz
	SRR24831180.fastq.gz	Fastqsanger.gz
	SRR24831181.fastq.gz	Fastqsanger.gz

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Decoding the gene promoters binding with BRD3 in LPS-primed THP1 monocytes

Project description:To screen the genes regulated by BRD3 in the THP1 monocytes induced by LPS, THP1 monocytes were treated by LPS for 1 hour in the presence or absence of OTX015

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Analysis of lncrna expression profile in LPS activated THP1 cells

Project description:In order to further explore the expression of lncrna in asthma, we used lipopolysaccharide (LPS) to activate human monocyte macrophage THP-1, and then used deep sequencing method to detect the expression of lncrna in activated and inactive THP1 cells. The results showed that there were different expression of lncrna in LPS activated and inactive THP1 cells

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LPS-stimulated THP1 monocytic cell line

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BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation

Project description:Understanding the precise functions and relationship of BRD2 with other bromodomain and extraterminal motif (BET) proteins is central for the application of BET-specific and pan inhibitors. Here, we used acute protein degradation and quantitative genomic and proteomic approaches to investigate the primary functions of BRD2 in transcription. We report that BRD2 is required for TAF3-mediated Pol II initiation at low levels of H3K4me3-modified promoters and Pol II elongation by suppressing R-loops. Single and double depletion revealed that BRD2 and BRD3, but not BRD4, redundantly and independently function in Pol II transcription at different promoters and cooperatively occupy enhancers. Interestingly, we found that depletion of BRD2 affects the expression of different genes during differentiation processes, priming with promoter regulation in ES cells. Therefore, our results suggest complex interconnections between BRD2 and BRD3 at promoters to fine-tune Pol II initiation and elongation for control of cell state.

2024-05-22 | PXD030774 | Pride

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