Ontology highlight
ABSTRACT:
PROVIDER: PRJNA981095 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Mardinoglu2014 - Genome-scale metabolic model
(HMR version 2.0) - human hepatocytes (iHepatocytes2322)
This model is described in the article:
Genome-scale metabolic
modelling of hepatocytes reveals serine deficiency in patients
with non-alcoholic fatty liver disease.
Mardinoglu A, Agren R, Kampf C,
Asplund A, Uhlen M, Nielsen J.
Nat Commun 2014; 5: 3083
Abstract:
Several liver disorders result from perturbations in the
metabolism of hepatocytes, and their underlying mechanisms can
be outlined through the use of genome-scale metabolic models
(GEMs). Here we reconstruct a consensus GEM for hepatocytes,
which we call iHepatocytes2322, that extends previous models by
including an extensive description of lipid metabolism. We
build iHepatocytes2322 using Human Metabolic Reaction 2.0
database and proteomics data in Human Protein Atlas, which
experimentally validates the incorporated reactions. The
reconstruction process enables improved annotation of the
proteomics data using the network centric view of
iHepatocytes2322. We then use iHepatocytes2322 to analyse
transcriptomics data obtained from patients with non-alcoholic
fatty liver disease. We show that blood concentrations of
chondroitin and heparan sulphates are suitable for diagnosing
non-alcoholic steatohepatitis and for the staging of
non-alcoholic fatty liver disease. Furthermore, we observe
serine deficiency in patients with NASH and identify PSPH,
SHMT1 and BCAT1 as potential therapeutic targets for the
treatment of non-alcoholic steatohepatitis.
This model is hosted on
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MODEL1402200003.
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2005-01-01 | MODEL1402200003 | BioModels
Project description:Non-alcoholic Fatty liver disease Stool, Diet and Plasma Samples
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Project description:Fatty liver disease and insulin resistance are common comorbidities, highlighting the potential for the liver to secrete factors that influence glycemic control. We assessed the influence of progressive liver disease, including non-alcoholic steatosis and non-alcoholic steatohepatitis on liver secreted extracellular vesicle secretion and composition.
2023-12-19 | PXD037924 | Pride
Project description:Non-alcoholic Fatty liver disease Stool, Diet and Plasma Samples
2024-12-05 | MSV000096602 | MassIVE
Project description:Global gene expression patterns of 2 human steatosis and 9 human non-alcoholic steatohepatitis (NASH) together with their respective control patterns were analyzed to define the non-alcoholic fatty liver disease (NAFLD) progression molecular characteristics and to define NASH early markers from steatosis. Human liver samples of steatosis and non-alcoholic steatohepatitis were selected for RNA extraction and hybridization on Affymetrix microarrays. This dataset is part of the TransQST collection.
2014-11-07 | E-GEOD-63067 | biostudies-arrayexpress
Project description:Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are major contributors of chronic liver disease. There is an urgent need to identity non-invasive biomarkers for early diagnosis. This project preformed secretome analysis of >100 human liver samples with various stages of NAFLD and NASH to identify potential biomarkers.
2025-04-13 | PXD019835 | Pride