Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The Tabulae Paralytica: Multimodal single-cell and spatial atlases of spinal cord injury

ABSTRACT: The Tabulae Paralytica: Multimodal single-cell and spatial atlases of spinal cord injury

PROVIDER: PRJNA982886 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24902600.fastq.gz	Fastqsanger.gz
	SRR24902700.fastq.gz	Fastqsanger.gz
	SRR24902800_1.fastq.gz	Fastqsanger.gz
	SRR24902800_2.fastq.gz	Fastqsanger.gz
	SRR24902900.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 616

Similar Datasets

The Tabulae Paralytica: Multimodal single-cell and spatial atlases of spinal cord injury

Project description:This submission is a dataset of two modalities, single-nucleus transcriptomics and single-nuclei spatial transcriptomics in the spinal cords of mice. The single-nuclei transcriptomics data is harvested and profiled using 10x Genomics Chromium Single Cell Kit Version. The single-nuclei spatial transcriptomics data is harvested and profiled using Visium Spatial Gene Expression.

2024-01-30 | GSE234774 | GEO

Spatial transcriptomics on human lumbar spinal cord

Project description:This study includes spatial transcriptomics on the human lumbar spinal cord using the 10x Genomics Visium platform. Frozen sections of spinal cord were placed on Visium slide arrays and processed using the 10x Genomics workflow, followed by alignment and quantification using the spaceranger package.

2023-01-31 | GSE222322 | GEO

Spatial transcriptomics and single-nucleus RNA-sequencing reveal a transcriptomic atlas of human spinal cord [Spinal spatial]

Project description:Despite the recognized importance of the spinal cord in sensory processing, motor behaviors, and neural diseases, the underlying organization of neuronal clusters and their spatial location remain elusive. Recently, several studies have attempted to define the neuronal types and functional heterogeneity in the spinal cord using single-cell or single-nucleus RNA sequencing in animal models or developing humans. However, molecular evidence of cellular heterogeneity in the adult human spinal cord is limited. Here, we classified spinal cord neurons into 21 subclusters and determined their distribution from nine human donors using single-nucleus RNA sequencing and spatial transcriptomics. Moreover, we compared the human findings with previously published single-nucleus data of the mouse adult spinal cord, which revealed an overall similarity in the neuronal composition of the spinal cord between the two species while simultaneously highlighting some degree of heterogeneity. Additionally, we examined the sex differences in the spinal neuronal subclusters. Several genes, such as SCN10A and HCN1, showed sex differences in motor neurons. Finally, we classified human DRG neurons using spatial transcriptomics and explored the putative interactions between DRG and spinal cord neuronal subclusters. In summary, these results illustrate the complexity and diversity of spinal neurons in humans and provide an important resource for future research to explore the molecular mechanisms underlying spinal cord physiology and diseases.

2024-01-11 | GSE243074 | GEO

Spatial transcriptomics on human lumbar spinal cord

Project description:Spatial transcriptomics on human lumbar spinal cord

| PRJNA919178 | ENA

Spatial transcriptomics and single-nucleus RNA-sequencing reveal a transcriptomic atlas of human spinal cord [DRG Spatial]

2024-01-11 | GSE243073 | GEO

Spatial transcriptomics and single-nucleus RNA-sequencing reveal a transcriptomic atlas of human spinal cord [Spinal snRNA-seq]

2024-01-11 | GSE243076 | GEO

Single cell transcriptome atlases of the developing mouse and human spinal cord

Project description:Single cell transcriptome atlases of the developing mouse and human spinal cord

| PRJNA721336 | ENA

Spinal cord injury

Project description:Spinal cord injury

| PRJNA532533 | ENA

single cell RNA-seq and Visium data of human spinal cord

Project description:The spinal cord is the critical part of the central nervous system. We performed scRNA-seq and Visum spatial RNA-seq to decipher the development of human spinal cord in the embryonic stage. Together, we reveal the dynamics of neural lineage and glial lineage during the development of human spinal cord.

2023-12-31 | GSE221692 | GEO

Spatial transcriptomics and single-nucleus RNA-sequencing reveal a transcriptomic atlas of human spinal cord [Spinal spatial]

Project description:Spatial transcriptomics and single-nucleus RNA-sequencing reveal a transcriptomic atlas of human spinal cord [Spinal spatial]

| PRJNA1016330 | ENA