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Nutrient-driven histone code determines exhausted CD8+ T cell fates

ABSTRACT: Nutrient-driven histone code determines exhausted CD8+ T cell fates

PROVIDER: PRJNA984745 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24952872_1.fastq.gz	Fastqsanger.gz
	SRR24952872_2.fastq.gz	Fastqsanger.gz
	SRR24952873_1.fastq.gz	Fastqsanger.gz
	SRR24952873_2.fastq.gz	Fastqsanger.gz
	SRR24952874_1.fastq.gz	Fastqsanger.gz

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Nutrient-driven histone code determines exhausted CD8+ T cell fates

Project description:Nutrient-driven histone code determines exhausted CD8+ T cell fates

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Nutrient-driven histone code determines exhausted CD8+ T cell fates [RNA-seq]

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Nutrient-driven histone code determines exhausted CD8+ T cell fates [ChIP-seq]

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Nutrient-driven histone code determines exhausted CD8+ T cell fates

Project description:Exhausted T cells (TEX) in cancer and chronic viral infections undergo metabolic and epigenetic remodeling, impairing protective capabilities. However, the impact of nutrient metabolism on epigenetic modifications that control TEX differentiation remains unclear. Our study reveals that TEX cells shift from acetate to citrate metabolism by downregulating acetyl-CoA synthetase 2 (ACSS2) while maintaining ATP-citrate lyase (ACLY) activity. This metabolic switch increases citrate-dependent histone acetylation, mediated by histone acetyltransferase KAT2A-ACLY interactions, at TEX signature-genes while reducing acetate-dependent histone acetylation, dependent on p300-ACSS2 complexes, at effector and memory T cell genes. Nuclear ACSS2 overexpression or ACLY inhibition prevents TEX differentiation and enhances tumor-specific T cell responses. These findings unveil a nutrient-driven histone code governing CD8+ T cell differentiation, with implications for metabolic- and epigenetic-based T cell therapies

2025-03-12 | GSE235195 | GEO

Nutrient-driven histone code determines exhausted CD8+ T cell fates [RNA-seq]

Project description:To investigate the role of ACSS2NLS in the regulation of CD8+ T cell responses in B16-GP33 tumor model Exhausted T cells (TEX) in cancer and chronic viral infections undergo metabolic and epigenetic remodeling, impairing protective capabilities. However, the impact of nutrient metabolism on epigenetic modifications that control TEX differentiation remains unclear. Our study reveals that TEX cells shift from acetate to citrate metabolism by downregulating acetyl-CoA synthetase 2 (ACSS2) while maintaining ATP-citrate lyase (ACLY) activity. This metabolic switch increases citrate-dependent histone acetylation, mediated by histone acetyltransferase KAT2A-ACLY interactions, at TEX signature-genes while reducing acetate-dependent histone acetylation, dependent on p300-ACSS2 complexes, at effector and memory T cell genes. Nuclear ACSS2 overexpression or ACLY inhibition prevents TEX differentiation and enhances tumor-specific T cell responses. These findings unveil a nutrient-driven histone code governing CD8+ T cell differentiation, with implications for metabolic- and epigenetic-based T cell therapies

2024-12-11 | GSE235006 | GEO

Nutrient-driven histone code determines exhausted CD8+ T cell fates [ChIP-seq]

Project description:To investigate the role of ACSS2 and ACLY in the regulation of epigenetic states of CD8+ T cells in cancer and chronic viral infections Exhausted T cells (TEX) in cancer and chronic viral infections undergo metabolic and epigenetic remodeling, impairing protective capabilities. However, the impact of nutrient metabolism on epigenetic modifications that control TEX differentiation remains unclear. Our study reveals that TEX cells shift from acetate to citrate metabolism by downregulating acetyl-CoA synthetase 2 (ACSS2) while maintaining ATP-citrate lyase (ACLY) activity. This metabolic switch increases citrate-dependent histone acetylation, mediated by histone acetyltransferase KAT2A-ACLY interactions, at TEX signature-genes while reducing acetate-dependent histone acetylation, dependent on p300-ACSS2 complexes, at effector and memory T cell genes. Nuclear ACSS2 overexpression or ACLY inhibition prevents TEX differentiation and enhances tumor-specific T cell responses. These findings unveil a nutrient-driven histone code governing CD8+ T cell differentiation, with implications for metabolic- and epigenetic-based T cell therapies

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Nutrient-driven histone code determines exhausted CD8+ T cell fates

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2024-12-11 | GSE235007 | GEO

Single-cell RNA-seq of human breast tumor samples with exhausted and non-exhausted immune environments

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