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Gene expression differences associated with intrinsic hindfoot muscle loss in the jerboa, Jaculus jaculus

ABSTRACT: Gene expression differences associated with intrinsic hindfoot muscle loss in the jerboa, Jaculus jaculus

PROVIDER: PRJNA988052 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25038971.fastq.gz	Fastqsanger.gz
	SRR25038972.fastq.gz	Fastqsanger.gz
	SRR25038973.fastq.gz	Fastqsanger.gz
	SRR25038974.fastq.gz	Fastqsanger.gz
	SRR25038975.fastq.gz	Fastqsanger.gz

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Gene expression differences associated with intrinsic hindfoot muscle loss in the jerboa, Jaculus jaculus

Project description:Muscle is a highly adaptable tissue capable of undergoing environmentally-induced changes and remarkable evolutionary adaptations. Muscle atrophy, a common feature in various myopathies as well as other conditions like cancer and diabetes, has been studied at the transcriptomic level, uncovering shared molecular factors. The lesser Egyptian jerboa, adapted for bipedal locomotion in a desert environment, experiences natural muscle loss in its foot. Cellular characterization of this process revealed similarities with human skeletal muscle atrophy, such as the loss of Desmin and upregulation of the ubiquitin proteasome pathway. By using RNA-sequencing, gene candidates associated with muscle loss in jerboa were identified, and genome-wide comparisons with established mouse models of muscle dystrophy/atrophy elucidated shared molecular signatures. These findings provide valuable insights into the genes and pathways involved in natural muscle loss and contribute to understanding the evolutionary relationship between natural and pathological muscle loss.

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Jaculus jaculus

Project description:Jaculus jaculus (Lesser Egyptian jerboa) genome, mJacJac1, paternal haplotype

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Jaculus jaculus isolate:mJacJac1

Project description:Jaculus jaculus (Lesser Egyptian jerboa) genome, mJacJac1, maternal haplotype

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Renal transcriptome of the desert adapted Jaculus jaculus during water restriction and rehydration

Project description:Jaculus jaculus were split into three experimental groups: control (water access ad libitum), dehydrated (11 days water restriction), and rehydrated (7 days water restriction followed by 3 days water ad libitum). Kidney samples were extracted and sequenced to investigate changes in gene expression during osmotic challenge in a desert adapted model.

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Jaculus jaculus strain:Lab Born/Non-Inbred

Project description:Jaculus jaculus Genome Sequencing

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Project description:Jaculus jaculus (Lesser Egyptian jerboa) genome, mJacJac1

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Jaculus jaculus

Project description:The lesser Egyptian jerboa is a small rodent adapted to desert and semi-arid habitats

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Project description:Jaculus jaculus (Lesser Egyptian jerboa) genome, mJacJac1, sequence data

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Renal transcriptome of the desert adapted Jaculus jaculus during water restriction and rehydration

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Intrinsic differences between oral and skin keratinocytes

Project description:The morphology and the behavior of skin and oral tissue keratinocytes are different. One significant dissimilarity between the two sites is the response to injury. Oral and skin keratinocytes have intrinsic differences in the response to injury and such differences are reflected in gene expression profiles. We used microarrays to investigate differences in global gene expression patterns between baseline skin and oral epithelium sheets without their underlying connective tissue. Paired skin and oral epithelium was separated from the dermis for RNA extraction and hybridization on Affymetrix microarrays. Skin epidermal tissues were obtained from the tail of mice and oral epidermal tissues were obtained from the hard palate. Enzymatically isolated epithelium was used for analysis.

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