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Single-cell analysis of the nervous system at small and large scales with instant partitions.

ABSTRACT: Single-cell analysis of the nervous system at small and large scales with instant partitions.

PROVIDER: PRJNA988523 | ENA |

REPOSITORIES: ENA

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Single-cell analysis of the nervous system at small and large scales with instant partitions.

Project description:Single-cell RNA sequencing is a new frontier across all biology, particularly in neuroscience. While powerful for answering numerous neuroscience questions, limitations in sample input size, and initial capital outlay can exclude some researchers from its application. Here, we tested a recently introduced method for scRNAseq across diverse scales and neuroscience experiments. We benchmarked against a major current scRNAseq technology and found that PIPseq performed similarly, in line with earlier benchmarking data. Across dozens of samples, PIPseq recovered many brain cell types at small and large scales (1,000-100,000 cells/sample) and was able to detect differentially expressed genes in an inflammation paradigm. Similarly, PIPseq could detect expected and new differentially expressed genes in a brain single cell suspension from a knockout mouse model; it could also detect rare, virally-labelled following AAV-targeting and gene knockdown. Finally, we used PIPseq to investigate gene expression in a nontraditional model species, the little skate (Leucoraja erinacea). In total, PIPSeq was equally able to detect gene expression changes across models and species, with an added benefit of large scale capture and sequencing of each sample.

2025-06-30 | GSE236063 | GEO

The immune landscapes of primary central nervous system diffuse large B cell lymphoma

Project description:The immune landscapes of primary central nervous system diffuse large B cell lymphoma

| PRJNA649580 | ENA

Deep sequencing of the locust Locusta migratoria manilensis central nervous system transcriptome

Project description:We report the application of single-molecule-based sequencing technology for high-throughput profiling of nervous system in locust Locusta migratoria manilensis. By obtaining over 57,000,000 bases of sequence from central nervous system, we generated 101836 contigs and 69440 scaffolds. We finally get 41179 unigene with an average length of 570bp. There are 5519 unigenes beyond the length of 1000bp. Using BLAST searches of the NR, NT, Swiss-Prot, KEGG and COG databases we are able to identify 13552 unigene (E<0.0001). Comprehensive assessment of all the unigenes by comparing with the studied genes of other insects nervous system reveals that our unigene are broadly representative of the transcriptome of insect nervous system. Our data provides the most large-scale EST-project for locust nervous system, which greatly benefits the exploring of this insect. In addition, we identify a large number of novel nervous genes which can be used in systematic studies of locust and other insects. Examination of 1 sample

2011-01-04 | E-GEOD-24498 | biostudies-arrayexpress

Peripheral nervous system tumors in neurofibromatosis

Project description:Peripheral nervous system tumors in neurofibromatosis

| PRJNA882036 | ENA

Efavirenz Central Nervous System Side Effects

Project description:Efavirenz Central Nervous System Side Effects

| PRJNA354669 | ENA

Deep sequencing of the locust Locusta migratoria manilensis central nervous system transcriptome

2011-01-04 | GSE24498 | GEO

Molecular topography of an entire nervous system

Project description:Molecular topography of an entire nervous system

| PRJNA561108 | ENA

Gene expression correlated with inattention and hyperactivity/impulsivity rating scales in Tourette syndrome

Project description:Inattention, impulsivity and hyperactivity are the primary behaviors associated with Attention Deficit / Hyperactivity Disorder (ADHD). Previous studies proved that peripheral blood gene expression signature could mirror central nervous system disease. This study determined if gene expression in blood correlated with inattention, hyperactivity/impulsivity rating scales and/or both in subjects with Tourette syndrome (TS).

2014-06-30 | GSE30470 | GEO

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

Project description:RATIONALE: Radiolabeled monoclonal antibodies, such as iodine I 131 monoclonal antibody 3F8, can find tumor cells and carry tumor-killing substances to them without harming normal cells. This may be an effective treatment for central nervous system cancer or leptomeningeal metastases. PURPOSE: This phase II trial is studying the side effects and how well iodine I 131 monoclonal antibody 3F8 works in treating patients with central nervous system cancer or leptomeningeal cancer.

| 2037925 | ecrin-mdr-crc

Pathway analysis of primary central nervous system lymphoma (PCNSL)

Project description:Primary central nervous system (CNS) lymphoma (PCNSL) is a diffuse large B cell lymphoma (DLBCL) confined to the CNS. A genome-wide gene expression comparison between PCNSL and non-CNS DLBCL was performed, the latter consisting of both nodal and extranodal DLBCL (nDLBCL and enDLBCL), to identify a “CNS signature.” Keywords: disease state analysis

2008-05-10 | GSE11392 | GEO

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