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Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases

ABSTRACT: Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases

PROVIDER: PRJNA989553 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25041712_1.fastq.gz	Fastqsanger.gz
	SRR25041712_2.fastq.gz	Fastqsanger.gz
	SRR25041713_1.fastq.gz	Fastqsanger.gz
	SRR25041713_2.fastq.gz	Fastqsanger.gz
	SRR25041714_1.fastq.gz	Fastqsanger.gz

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Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases [RNA-seq]

Project description:Most DNA variants associated with common complex diseases fall outside the protein-coding regions of the genome, making them hard to detect and relate to a function. Although many computational tools are available for prioritizing functional disease risk variants outside the protein-coding regions of the genome, the precision of prediction of these tools is mostly unreliable and hence not close to cancer risk prediction. This study brings to light a novel way to improve prediction accuracy of publicly available tools by integrating the impact of cis-overlapping binding sites of opposing cancer proteins, such as P53 and cMYC, in their analysis to filter out deleterious DNA variants outside the protein-coding regions of the human genome. Using a biology-based statistical approach, DNA variants within cis-overlapping motifs impacting the binding affinity of opposing transcription factors can significantly alter the expression of target genes and regulatory networks. This study brings us closer to developing a generally applicable approach capable of filtering etiological non-coding variations in co-occupied genomic regions of P53 and cMYC family members to improve disease risk assessment.

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Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases [ChIP-seq]

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Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases [ChIP-seq]

Project description:Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases [ChIP-seq]

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Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases [RNA-seq]

Project description:Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases [RNA-seq]

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Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases

Project description:This SuperSeries is composed of the SubSeries listed below.

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Gene expression analysis of cMyc-deficient CD8 T cells retrovirally overexpressing cMyc or AP4

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Gene expression analysis of cMyc-deficient CD8 T cells retrovirally overexpressing cMyc or AP4

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