Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Genome-wide gene expression differences between Crohn’s and ulcerative colitis from endoscopic pinch biopsies:

OTHER RELATED OMICS DATASETS IN: E-GEOD-6731

PROVIDER: PRJNA98959 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Genome-wide gene expression differences between Crohn’s and ulcerative colitis from endoscopic pinch biopsies:

Project description:Ulcerative colitis (UC) and Crohn’s disease (CD) are inflammatory bowel diseases (IBD) with variable, overlapping clinical features and complex pathophysiologies. To identify pathogenic processes underlying these disease subtypes, using single endoscopic pinch biopsies to estabolish 36 expression profiles, we elucidated gene expression patterns of active and inactive areas of UC and CD, and compared these to infectious colitis and healthy controls. Keywords: RNA

2007-03-01 | GSE6731 | GEO

Definition of an ulcerative colitis preinflammatory state

Project description:The samples are a part of a study aiming at diagnosing ulcerative colitis from genome-wide gene expression analysis of the colonic mucosa. Colonic mucosal samples were collected as endoscopic pinch biopsies from ulcerative colitis patients and from control subjects. Samples with and without macroscopic signs of inflammation were collected from the patients. Keywords: Disease state analysis

2007-10-31 | GSE9452 | GEO

Transcription profiling of human ulcerative colitis colonic mucosa to define an ulcerative colitis preinflammatory state

2008-06-20 | E-GEOD-9452 | biostudies-arrayexpress

Transcription profiling of human colon biopsies obtained from patients with ulcerative colitis, Chrohn's disease vs. normal to identify pathogenic processes underlying these disease subtypes

Project description:Ulcerative colitis (UC) and Crohns disease (CD) are inflammatory bowel diseases (IBD) with variable, overlapping clinical features and complex pathophysiologies. To identify pathogenic processes underlying these disease subtypes, using single endoscopic pinch biopsies to estabolish 36 expression profiles, we elucidated gene expression patterns of active and inactive areas of UC and CD, and compared these to infectious colitis and healthy controls.To identify pathogenic processes underlying these disease subtypes, using single endoscopic pinch biopsies, we elucidated gene expression patterns of active and inactive areas of UC and CD, and compared these to infectious colitis and healthy controls. An unsupervised classification of a total of 36 samples yielded promising separation between IBD affected, unaffected, non-IBD colitis and normal controls, suggesting distinctive gene expression patterns for each sample type. The Significance Analysis of Microarays (SAM) software to select biologically significant changes in gene expression between groups. The criteria selected for SAM analysis are, a median false discovery rate (FDR) ? 0.00001%, fold change >2, and a Log2 mean expression index > 6.64.

2007-11-02 | E-GEOD-6731 | biostudies-arrayexpress

Single cell sequencing of frozen mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis

Project description:Single cell sequencing of frozen mucosal pinch biopsies from four colonic regions of patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis, as well as one healthy control. Pinch biopsies from each region were thawed, digested and pooled with 3 other donor biopsies and subjected to 5' 10x Chromium Next GEM cell RNA sequencing.

2026-06-26 | E-MTAB-16401 | biostudies-arrayexpress

Single cell sequencing of mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis

Project description:Mucosal pinch biopsies from ascending, transverse, descending colon and rectum were obtained from ulcerative colitis (UC) and primary sclerosing cholangitis concomitant with colitis (PSC-UC) patients during routine endoscopies and subjected to 5' single-cell RNA sequencing

2026-06-17 | E-MTAB-14955 | biostudies-arrayexpress

V(D)J TCR single cell sequencing of frozen mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis

Project description:Mucosal pinch biopsies from ascending, transverse, descending colon and rectum were obtained from ulcerative colitis (UC), primary sclerosing cholangitis concomitant with colitis (PSC-UC) and healthy control patients during routine endoscopies and cryopreserved. Biopsies were then thawed, digested and subjected to 5' single-cell RNA sequencing with V(D)J TCR analysis.

2026-06-29 | E-MTAB-17148 | biostudies-arrayexpress

V(D)J BCR single cell sequencing of frozen mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis

2026-07-03 | E-MTAB-17213 | biostudies-arrayexpress

V(D)J TCR single cell sequencing of mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis

2026-06-17 | E-MTAB-14899 | biostudies-arrayexpress

V(D)J BCR single cell sequencing of mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis

2026-06-17 | E-MTAB-14901 | biostudies-arrayexpress