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Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation [MDA-MB-231-RNASeq]

ABSTRACT: Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation [MDA-MB-231-RNASeq]

PROVIDER: PRJNA989607 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25099154.fastq.gz	Fastqsanger.gz
	SRR25099155.fastq.gz	Fastqsanger.gz
	SRR25099156.fastq.gz	Fastqsanger.gz
	SRR25099157.fastq.gz	Fastqsanger.gz
	SRR25099158.fastq.gz	Fastqsanger.gz

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Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation [MDA-MB-231-meRIPSeq]

Project description:Here we show that nitric oxide (NO) is a potent inhibitor of FTO demethylase activity by directly binding to the catalytic iron center, which causes global m6A hypermethylation of mRNA in cells and results in gene-specific enrichment of m6A on mRNA of NO-regulated transcripts. Both cell culture and tumor xenograft models demonstrated that endogenous NO synthesis can regulate m6A-mRNA levels and transcriptional changes of m6A-associated genes. These results build a direct link between NO and m6A-mRNA regulation and reveal a novel signaling mechanism of NO as an endogenous regulator of the epitranscriptome.

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Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation

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Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation [MDA-MB-231-meRIPSeq]

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