Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide CRISPR screen reveals tumor-intrinsic responses to radiotherapy

ABSTRACT: Genome-wide CRISPR screen reveals tumor-intrinsic responses to radiotherapy

PROVIDER: PRJNA990575 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25113466_1.fastq.gz	Fastqsanger.gz
	SRR25113466_2.fastq.gz	Fastqsanger.gz
	SRR25113467_1.fastq.gz	Fastqsanger.gz
	SRR25113467_2.fastq.gz	Fastqsanger.gz
	SRR25113468_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Genome-wide CRISPR screen reveals tumor-intrinsic responses to radiotherapy

Project description:Radiation therapy (RT) is one of the most commonly used anti-cancer therapies. However, the landscape of cellular response to irradiation, especially to a single high-dose irradiation, remains largely unknown. In this study, we performed a whole-genome CRISPR loss-of-function screen and revealed temporal inherent and acquired responses to RT. Specifically, we found that loss of the IL1R1 pathway led to cellular resistance to RT. This is in part due to the involvement of radiation-induced IL1R1-dependent transcriptional regulation, which relies on the NF-κB pathway. Moreover, the mitochondrial anti-apoptotic pathway, particularly the BCL2L1 gene, is crucially important for cell survival following radiation. BCL2L1 inhibition combined with RT dramatically impeded tumor growth in several breast cancer cell lines and syngeneic models. Taken together, our results suggest that the combination of an apoptosis inhibitor such as a BCL2L1 inhibitor with RT may represent a promising anti-cancer strategy for solid cancers including breast cancer.

2023-07-06 | GSE236331 | GEO

CRISPR screen

Project description:CRISPR screen

2023-04-25 | OEX00023089 | NODE

CRISPR-screen

Project description:CRISPR screen

2025-05-29 | OEX00031508 | NODE

CRISPR-screen

Project description:CRISPR screen

2025-03-27 | OEX00031362 | NODE

Intrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems [Screen]

Project description:Intrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems [Screen]

| PRJNA837526 | ENA

Homo sapiens

Project description:Genome-wide CRISPR screen reveals tumor-intrinsic responses to radiotherapy

| PRJNA989528 | ENA

CRISPR-Cas9 RBM10 synthetic lethality screen

Project description:Genome-wide CRISPR-Cas9 knockout screen using TKOv1 sgRNA library was performed in isogenic RBM10-proficient and RBM10-deficient HCC827 cells.

2023-03-04 | E-MTAB-12724 | biostudies-arrayexpress

FaDu RT CRISPR Screen

Project description:FaDu RT CRISPR Screen

| PRJNA612971 | ENA

HMGA2 project, CRISPR screen

Project description:HMGA2 project, CRISPR screen

| PRJNA718268 | ENA

Identify proinsulin regulators using CRISPR screen and mouse genetics [CRISPR screen]

Project description:Identify proinsulin regulators using CRISPR screen and mouse genetics [CRISPR screen]

| PRJNA1030057 | ENA