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Ralstonia pseudosolanacearum GMI1000

ABSTRACT: Regulation of bacterial physiology and virulence by the second messenger 2',3'-cyclic guanosine monophosphate

PROVIDER: PRJNA990578 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25119062_1.fastq.gz	Fastqsanger.gz
	SRR25119062_2.fastq.gz	Fastqsanger.gz
	SRR25119063_1.fastq.gz	Fastqsanger.gz
	SRR25119063_2.fastq.gz	Fastqsanger.gz
	SRR25119064_1.fastq.gz	Fastqsanger.gz

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Project description:2’3’-cyclic GMP-AMP (cGAMP) is a cyclic dinucleotide second messenger in which guanosine and adenosine are connected by one 3’-5’ and one 2’-5’ phosphodiester linkage. It is formed in the cytosol upon detection of pathogenic DNA by the enzyme guanosine-monophosphate-adenosine monophosphate synthase (cGAS). cGAMP subsequently binds to the adaptor protein stimulator of interferon genes (STING) to elicit an innate immune response leading to the production of type I interferons and cytokines. STING agonists are a highly promising avenue for an immuno-oncological anticancer therapy. A particular challenge with cyclic dinucleotide STING agonists are the two negative charges of the phosphodiester linkages, which strongly reduce the ability of such compounds to penetrate cell membranes. The development of cell-permeable STING agonists that can stimulate the immune system to enhance their anticancer potency is currently of utmost importance in the field. Here, we report the development of a dideoxy derivative of cGAMP as a phosphotriester prodrug, where the negative charge of the phosphate backbone has been masked with a thioester. We found that this thioester-protected compound features a dramatic increase in its cellular potency that rises from EC50 = 5 µM to 25 nM. The new compound is envisioned to enable an efficient STING-agonist-based anticancer therapy.

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