Project description:Postmenopausal osteoporosis is a prevalent clinical disorder in women. To elucidate the therapeutic mechanism underlying the combination of Juglans regia L. and Psoralea corylifolia Linn. for postmenopausal osteoporosis, we established bilateral ovariectomy-induced osteoporotic rat models and performed transcriptomic profiling. The results revealed that the anti-osteoporotic effects are predominantly mediated through ferroptosis-related pathways.
Project description:For tree crops, shortening juvenile phase is a vital strategy for early flowering that ensure to bear fruits in advance to enhance breeding efficiency. In walnut (Juglans regia L.), it usually takes 3-5 years for blooming, but the early flowering (EF) walnut can even flower in a year after planted. The juvenile phase of EF walnut is shorter than the late flowering (LF) walnut, which is more propitious to breeding efficiency. In this study, using RNA sequencing (RNA-seq) and microRNA-seq, we profiled transcriptome-wide identification of gene expression and microRNAs between EF and LF walnuts.
