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Interconnected lineage trajectories link conventional and NK-like exhausted CD8+ T cells beneficial in T1D

ABSTRACT: Interconnected lineage trajectories link conventional and NK-like exhausted CD8+ T cells beneficial in T1D

PROVIDER: PRJNA996033 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25335800_1.fastq.gz	Fastqsanger.gz
	SRR25335800_2.fastq.gz	Fastqsanger.gz
	SRR25335801_1.fastq.gz	Fastqsanger.gz
	SRR25335801_2.fastq.gz	Fastqsanger.gz
	SRR25335802_1.fastq.gz	Fastqsanger.gz

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Interconnected lineage trajectories link conventional and NK-like exhausted CD8+ T cells beneficial in T1D [P452_3]

Project description:While distinct NK-like CD57+ and PD-1+ CD8+ exhausted T cell populations (Tex) were both linked to beneficial immunotherapy response in autoimmune Type 1 Diabetes (T1D) patients, relationships between these cell types are poorly understood. We show that PD-1+ and CD57+ Tex populations in this context were epigenetically similar, but CD57+ Tex cells displayed unique increased chromatin accessibility of inhibitory Killer Cell Immunoglobulin-like Receptor (iKIR) and other NK cell genes. PD-1+ and CD57+ Tex also showed reciprocal expression of Inhibitory Receptors (IRs) and iKIRs accompanied by chromatin accessibility of Tcf1 and Tbet transcription factor target sites, respectively. CD57+ Tex showed unappreciated gene expression heterogeneity and shared clonal relationships with PD-1+ Tex, with these cells differentiating along four interconnected lineage trajectories: Tex-PD-1+, Tex-CD57+, Tex-Branching, and Tex-Fluid. Our findings demonstrate new relationships between Tex populations in human autoimmune disease and suggest that modulating common precursor populations may enhance response to autoimmune disease treatment.

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Interconnected lineage trajectories link conventional and NK-like exhausted CD8+ T cells beneficial in T1D [P362-1]

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Interconnected lineage trajectories link conventional and NK-like exhausted CD8+ T cells beneficial in T1D [P452_3]

Project description:Interconnected lineage trajectories link conventional and NK-like exhausted CD8+ T cells beneficial in T1D [P452_3]

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Interconnected lineage trajectories link conventional and NK-like exhausted CD8+ T cells beneficial in T1D [P362-1]

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Interconnected lineage trajectories link conventional and NK-like exhausted CD8+ T cells beneficial in T1D

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Project description:WTCCC1 project Type 1 Diabetes (T1D) samples

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