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Peromyscus leucopus breed:LL

ABSTRACT: Transcriptomes of spleens of Peromyscus leucopus with and without infection by Borreliella burgdorferi

PROVIDER: PRJNA996174 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25385729_1.fastq.gz	Fastqsanger.gz
	SRR25385729_2.fastq.gz	Fastqsanger.gz
	SRR25385730_1.fastq.gz	Fastqsanger.gz
	SRR25385730_2.fastq.gz	Fastqsanger.gz
	SRR25385731_1.fastq.gz	Fastqsanger.gz

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Borrelia burgdorferi fitness is constrained during Peromyscus leucopus infection

Project description:The Lyme disease spirochete Borrelia burgdorferi drives a range of acute and chronic maladies in humans and other incidental hosts infected with the pathogen. However, the primary vertebrate reservoir, Peromyscus leucopus appears spared from any symptomology following infection. This has led to a common hypothesis that P. leucopus and B. burgdorferi exist symbiotically: P. leucopus restrain their immune response against the microbe and enable the enzootic cycle while B. burgdorferi avoids causing damage to the host. While aspects of this hypothesis have been tested, the exact interactions that occur between P. leucopus and B. burgdorferi during infection remain largely unknown. Here we utilized an inbred colony of P. leucopus in order to compare B. burgdorferi (B31) fitness in these rodents to the traditional B. burgdorferi murine models—C57BL/6J and C3H/HeN Mus musculus, which develop signs of inflammation akin to human disease. We find that in contrast to our expectations, B. burgdorferi were able to reach much higher burdens in M. musculus, and that the overall kinetics of infection differed between the two rodent species. Surprisingly, we also found that P. leucopus remained infectious to larval Ixodes scapularis for a far shorter period than either M. musculus strain. In line with these observations, we found that P. leucopus does launch a modest but sustained inflammatory response against B. burgdorferi in the skin, which we hypothesize leads to reduced bacterial viability and infectivity in these hosts. These observations provide new insight into the nature of reservoir species and the B. burgdorferi enzootic cycle.

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Peromyscus leucopus breed:LL

Project description:Peromyscus leucopus fibroblast transcriptome

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Project description:Peromyscus leucopus transcriptomes of various organs and tissues

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Project description:Peromyscus leucopus transcriptomes in response to SARS-CoV-2 infection

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Evaluation of Peromyscus leucopus Bone Marrow-Derived Macrophage Responses to Borrelia burgdorferi and Lipopolysaccharide

Project description:Currently, most tools utilized in host-pathogen interaction studies depend on the use of human or mouse (Mus musculus) cells and tissues. While these species have led to countless breakthroughs in our understanding of infectious disease, there are undoubtably important biological processes that are missed by limiting studies to these two vertebrate species. For instance, it is well-established that the most common North American rodent, the Peromyscus leucopus deermouse, has unique interactions with microbes, which likely shape its ability to serve as a critical reservoir for at numerous zoonotic pathogens—including a Lyme disease spirochete, Borrelia burgdorferi. In this work, we expand the immunological toolkit to study P. leucopus biology by performing the first differentiation of deermouse bone marrow to macrophages using P. leucopus M-CSF producing HEK293T cells.

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Peromyscus leucopus breed:LL Stock

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Peromyscus leucopus breed:LL stock

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Peromyscus leucopus strain:LL

Project description:RNA sequencing of Peromyscus leucopus lung infected with SARS-CoV-2