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Music compensates for altered gene expression in age-related cognitive disorders

ABSTRACT: Music compensates for altered gene expression in age-related cognitive disorders

PROVIDER: PRJNA998755 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25431400_1.fastq.gz	Fastqsanger.gz
	SRR25431400_2.fastq.gz	Fastqsanger.gz
	SRR25431401_1.fastq.gz	Fastqsanger.gz
	SRR25431401_2.fastq.gz	Fastqsanger.gz
	SRR25431402_1.fastq.gz	Fastqsanger.gz

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Music compensates for altered gene expression in age-related cognitive disorders

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Project description:Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathways were compared to those dysregulated in mild cognitive impairment (MCI) and Alzheimer's disease (AD) as revealed by a multi-cohort study (n = 1269 MCI/AD and controls). Music was associated with 2.3 times more whole-genome gene expression, particularly on neurodegeneration-related genes, in ACD than in controls. Co-expressed gene-modules and pathways analysis demonstrated that music impacted autophagy, vesicle and endosome organization, biological processes commonly dysregulated in MCI/AD. Notably, the data indicated a strong negative correlation between musically-modified genes/pathways in ACD and those dysregulated in MCI/AD. These findings highlight the compensatory effect of music on genes/biological processes affected in MCI/AD, providing insights into the molecular mechanisms underlying the benefits of music on these disorders.

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