Alzheimer's disease (AD) is a chronic neurodegenerative disorder, accounting for up to 75 % of all dementia cases. Although the basis of AD etiology remains unknown, oxidative stress constitutes a major driver given its intimate association, specially at prodromic stages of the disease. In this line...
We performed proteomic profiling of the brain and retina in 3xTg-AD mouse model of Alzheimer's disease at one month of age to uncover early retinal signatures that may precede disease manifestations.
