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ProteomicsFunctional effects of CYP3A-CYP2E1 interactions and their role in activation of CYP3A enzymes by chronic alcohol exposure
Aiming to examine the effect of chronic alcohol exposure on the activity of CYP3A enzymes in human liver, we studied the metabolism of two CYP3A-specific substrates, 7-benzyloxyquinoline (7-BQ) and ivermectin, in 23 preparations of human liver microsomes (HLM) obtained from donors with documented al...
ORGANISM(S): Homo sapiens (Human) 
2026-09-18 | PXD079247 | Pride
Cytochrome p450  cyp2e1  cyp3a4  cyp3a5  nadph-cytochrome p450 reductase  pro-tein-protein interactions  7-benzyloxyquinoline  ivermectin  human liver microsomes  alcohol consumption  alcohol-drug interactions  cross-linking mass spectrometry 
UnknownLigand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection.
Not available
S-EPMC2683693 | biostudies-literature
UnknownEffects of alcohol-induced increase in CYP2E1 content in human liver microsomes on the activity and cooperativity of CYP3A4.
Not available
S-EPMC7856178 | biostudies-literature
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